Rabbit Anti-USP15 Polyclonal Antibody – Cat# MBS6361856

USP15 Antibody – Rabbit Polyclonal

Name: USP15 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6361856
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6361856

Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly… More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

USP15, Polyclonal Antibody

Full Product Name

USP15, NT (USP15, KIAA0529, Ubiquitin carboxyl-terminal hydrolase 15, Deubiquitinating enzyme 15, Ubiquitin thioesterase 15, Ubiquitin-specific-processing protease 15, Unph-2, Unph4) (MaxLight 490)

Product Gene Name

anti-USP15 antibody

Product Synonym Names

USP15; KIAA0529; Ubiquitin carboxyl-terminal hydrolase 15; Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15; Unph-2; Unph4

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

27,094 Da

OMIM

604731

3D Structure

ModBase 3D Structure for Q9Y4E8

Immunogen

USP15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the N-terminal region of human USP15.

Conjugate

MaxLight490

Note

Preservative Free

Product Categories/Family for anti-USP15 antibody

Antibodies; Ubiquitin

Applications Tested/Suitable for anti-USP15 antibody

Western Blot (WB), FLISA

Application Notes for anti-USP15 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-USP15 antibody

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Vos, R.M., et al. J. Virol. 83(17):8885-8892(2009). Huang, X., et al. J. Mol. Biol. 391(4):691-702(2009). Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007): Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006).

Other Notes

Small volumes of anti-USP15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for USP15 purchase

MBS6361856 is an antibody targeting USP15. Also known as USP15, NT (USP15, KIAA0529, Ubiquitin carboxyl-terminal hydrolase 15, Deubiquitinating enzyme 15, Ubiquitin thioesterase 15, Ubiquitin-specific-processing protease 15, Unph-2, Unph4) (MaxLight 490). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for USP15. It may not necessarily be applicable to this product.

NCBI GI #

14149627

NCBI GeneID

9958

NCBI Accession #

NP_006304.1

UniProt Primary Accession #

Q9Y4E8

UniProt Secondary Accession #

Q08AL5; Q9H8G9; Q9HCA6; Q9UNP0; Q9Y5B5

UniProt Related Accession #

Q9Y4E8

GenBank Nucleotide #

NM_006313.2

NCBI Official Full Name

ubiquitin carboxyl-terminal hydrolase 15 isoform 2

NCBI Official Synonym Full Names

ubiquitin specific peptidase 15

NCBI Official Symbol

USP15

NCBI Official Synonym Symbols

UNPH4; UNPH-2

UniProt Protein Name

Ubiquitin carboxyl-terminal hydrolase 15

UniProt Synonym Protein Names

Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15; Unph-2; Unph4

UniProt Gene Name

USP15

UniProt Synonym Gene Names

KIAA0529

UniProt Entry Name

UBP15_HUMAN

NCBI Protein Information

ubiquitin carboxyl-terminal hydrolase 15; ubiquitin thioesterase 15; deubiquitinating enzyme 15; ubiquitin thiolesterase 15; ubiquitin-specific-processing protease 15

NCBI Summary for USP15

This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

UniProt Comments for USP15

USP15: Protease that degrades 'Lys-48'-linked polyubiquitin chains. Protects target proteins against proteasomal degradation. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Ubiquitin-specific protease; EC 3.4.19.12; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 12q14

Cellular Component: cytoplasm; nucleus

Molecular Function: identical protein binding; protein binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; SMAD binding; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; transforming growth factor beta receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway

Research Articles on USP15

1. Data suggest that ubiquitin specific peptidase 15 (USP15) may play a role in the pathogenesis of psoriasis through regulating the type I TGFbeta receptor (TbetaR-I)/Smad7 pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-USP15 antibody

Reference Product	PubMed Publications
SMAD7 antibody	>3 publications with USP15 and SMAD7
SMURF2 antibody	>2 publications with USP15 and SMURF2
SART3 antibody	>2 publications with USP15 and SART3

Pathways associated with anti-USP15 antibody

Products by Pathway	Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Downregulation Of TGF-beta Receptor Signaling Pathway antibodies	Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
Integrated Breast Cancer Pathway antibodies	Integrated Breast Cancer Pathway Diagram
Loss Of Function Of SMAD2/3 In Cancer Pathway antibodies	Loss Of Function Of SMAD2/3 In Cancer Pathway Diagram
Loss Of Function Of SMAD4 In Cancer Pathway antibodies	Loss Of Function Of SMAD4 In Cancer Pathway Diagram
Loss Of Function Of TGFBR1 In Cancer Pathway antibodies	Loss Of Function Of TGFBR1 In Cancer Pathway Diagram
Loss Of Function Of TGFBR2 In Cancer Pathway antibodies	Loss Of Function Of TGFBR2 In Cancer Pathway Diagram
SMAD2/3 MH2 Domain Mutants In Cancer Pathway antibodies	SMAD2/3 MH2 Domain Mutants In Cancer Pathway Diagram
SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway antibodies	SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway Diagram
SMAD4 MH2 Domain Mutants In Cancer Pathway antibodies	SMAD4 MH2 Domain Mutants In Cancer Pathway Diagram

Diseases associated with anti-USP15 antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>4 publications with USP15 and Breast Neoplasms
Disease Models, Animal Antibodies	>2 publications with USP15 and Disease Models, Animal
Heart Diseases Antibodies	>2 publications with USP15 and Heart Diseases
Necrosis Antibodies	>2 publications with USP15 and Necrosis
Immune System Diseases Antibodies	>1 publications with USP15 and Immune System Diseases
Drug-Related Side Effects and Adverse Reactions Antibodies	>1 publications with USP15 and Drug-Related Side Effects and Adverse Reactions
Nervous System Diseases Antibodies	>1 publications with USP15 and Nervous System Diseases
Brain Diseases Antibodies	>1 publications with USP15 and Brain Diseases
Hyperplasia Antibodies	>1 publications with USP15 and Hyperplasia
Inflammation Antibodies	>1 publications with USP15 and Inflammation

Organs/Tissues associated with anti-USP15 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>5 publications with USP15 and Blood
Bone Antibodies	>4 publications with USP15 and Bone
Brain Antibodies	>4 publications with USP15 and Brain
Heart Antibodies	>2 publications with USP15 and Heart
Vascular Antibodies	>2 publications with USP15 and Vascular
Embryonic Tissue Antibodies	>2 publications with USP15 and Embryonic Tissue
Skin Antibodies	>1 publications with USP15 and Skin
Stomach Antibodies	>1 publications with USP15 and Stomach
Muscle Antibodies	>1 publications with USP15 and Muscle