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WARS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8572629

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
WARS, Polyclonal Antibody
Full Product Name
WARS Polyclonal Antibody
Product Gene Name
anti-WARS antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
48kDa; 53kDa
OMIM
191050
3D Structure
ModBase 3D Structure for P23381
Immunogen
Recombinant protein of human WARS (NP_776049.1).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-WARS antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-WARS antibody
WB: 1:500-1:2000
IF: 1:10-1:100

Other Notes

Small volumes of anti-WARS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WARS purchase

MBS8572629 is an antibody targeting WARS. Also known as WARS Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for WARS. It may not necessarily be applicable to this product.

NCBI GI #
47419914
NCBI GeneID
7453
NCBI Accession #
NP_004175.2
UniProt Primary Accession #
P23381
UniProt Related Accession #
P23381
GenBank Nucleotide #
NP_004175.2
NCBI Official Full Name
tryptophan--tRNA ligase, cytoplasmic isoform a
NCBI Official Synonym Full Names
tryptophanyl-tRNA synthetase 1
NCBI Official Symbol
WARS1
NCBI Official Synonym Symbols
HMN9; WARS; IFI53; IFP53; GAMMA-2
UniProt Protein Name
Tryptophan--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names
Interferon-induced protein 53; IFP53; Tryptophanyl-tRNA synthetase; TrpRS; hWRS
Protein Family
Tryptophan--tRNA ligase
UniProt Gene Name
WARS
UniProt Synonym Gene Names
IFI53; WRS; IFP53; TrpRS; hWRS
UniProt Entry Name
SYWC_HUMAN
NCBI Protein Information
tryptophan--tRNA ligase, cytoplasmic

UniProt Comments for WARS

WARS: Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Belongs to the class-I aminoacyl-tRNA synthetase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - tryptophan; Translation; Ligase; EC 6.1.1.2

Chromosomal Location of Human Ortholog: 14q32.31

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; tryptophan-tRNA ligase activity; ATP binding

Biological Process: negative regulation of cell proliferation; tRNA aminoacylation for protein translation; tryptophanyl-tRNA aminoacylation; translation; gene expression; angiogenesis; regulation of angiogenesis
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Research Articles on WARS

1. Inhibition of human tryptophanyl-tRNA synthetase (TrpRS) expression by TrpRS-specific siRNAs decreased and overexpression of TrpRS increased Trp uptake into the cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-WARS antibody

 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram

Diseases associated with anti-WARS antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1628 publications with WARS and Cardiovascular Diseases
 Pain Antibodies  >953 publications with WARS and Pain
 Poisoning Antibodies  >927 publications with WARS and Poisoning
 Heart Diseases Antibodies  >727 publications with WARS and Heart Diseases
 Inflammation Antibodies  >357 publications with WARS and Inflammation
 Hypertension Antibodies  >319 publications with WARS and Hypertension
 Memory Disorders Antibodies  >268 publications with WARS and Memory Disorders
 Kidney Diseases Antibodies  >264 publications with WARS and Kidney Diseases
 Breast Neoplasms Antibodies  >257 publications with WARS and Breast Neoplasms
 Cognition Disorders Antibodies  >218 publications with WARS and Cognition Disorders

Organs/Tissues associated with anti-WARS antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3052 publications with WARS and Blood
 Brain Antibodies  >2920 publications with WARS and Brain
 Bone Antibodies  >1274 publications with WARS and Bone
 Heart Antibodies  >1004 publications with WARS and Heart
 Skin Antibodies  >961 publications with WARS and Skin
 Lung Antibodies  >921 publications with WARS and Lung
 Vascular Antibodies  >883 publications with WARS and Vascular
 Nerve Antibodies  >809 publications with WARS and Nerve
 Eye Antibodies  >754 publications with WARS and Eye
 Muscle Antibodies  >524 publications with WARS and Muscle
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