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WDR5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6460204

MBS6460204 is an antibody targeting Wdr5. Also known as Wdr5 (WD Repeat-Containing Protein 5, BMP2-Induced 3-kb gene Protein, WD Repeat-Containing Protein BIG-3, Wdr5, Big, Big3) (MaxLight 405). Reactive in Human, Mouse. Host: Rabbit. More details

$1025 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Wdr5, Polyclonal Antibody
Full Product Name
Wdr5 (WD Repeat-Containing Protein 5, BMP2-Induced 3-kb gene Protein, WD Repeat-Containing Protein BIG-3, Wdr5, Big, Big3) (MaxLight 405)
Product Gene Name
anti-Wdr5 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes Wdr5. Species Crossreactivity: human, mouse
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
36,588 Da
3D Structure
ModBase 3D Structure for P61965
Immunogen
KLH conjugated synthetic peptide between at the region of mouse Wdr5. Species sequence homology: rat
Conjugate
MaxLight405
Note
Preservative Free

Product Categories/Family for anti-Wdr5 antibody

Antibodies; WD Repeat Proteins
Applications Tested/Suitable for anti-Wdr5 antibody
Western Blot (WB)
Application Notes for anti-Wdr5 antibody
WB: 1:1000
Applications are based on unconjugated antibody.

Product References and Citations for anti-Wdr5 antibody

Gori F., et al. J. Biol. Chem. 276:46515-46522(2001). Carninci P., et al. Science 309:1559-1563(2005). Jiang H., et al. Cell 144:513-525(2011). Yang Y.J., et al. Cell 151:1097-1112(2012). Diao Y., et al. Cell Stem Cell 11:231-241(2012).

Other Notes

Small volumes of anti-Wdr5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Wdr5. It may not necessarily be applicable to this product.

NCBI GI #
18252790
NCBI GeneID
140858
NCBI Accession #
NP_543124.1
UniProt Primary Accession #
P61965
UniProt Secondary Accession #
Q498M4; P61964
UniProt Related Accession #
P61965
GenBank Nucleotide #
NM_080848.2
NCBI Official Full Name
WD repeat-containing protein 5
NCBI Official Synonym Full Names
WD repeat domain 5
NCBI Official Symbol
Wdr5
NCBI Official Synonym Symbols
Big; Big-3; AA408785; AA960360; 2410008O07Rik
UniProt Protein Name
WD repeat-containing protein 5
UniProt Synonym Protein Names
BMP2-induced 3-kb gene protein; WD repeat-containing protein BIG-3
Protein Family
WD repeat-containing protein
UniProt Gene Name
Wdr5
UniProt Synonym Gene Names
Big; Big3
NCBI Protein Information
WD repeat-containing protein 5

UniProt Comments for Wdr5

WDR5: a WD40 repeat protein. May accelerate osteoblast differentiation. Interacts with HCFC1. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2|2 A3

Cellular Component: histone acetyltransferase complex; histone methyltransferase complex; intracellular; nucleoplasm; nucleus

Molecular Function: histone acetyltransferase activity (H4-K16 specific); histone methyltransferase activity (H3-K4 specific); methylated histone residue binding; protein binding

Biological Process: covalent chromatin modification; histone H3-K4 methylation; neuron projection development; regulation of transcription, DNA-templated; skeletal system development; transcription, DNA-dependent
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Research Articles on Wdr5

1. Cbx8 associates with non-PRC1 complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch gene expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Wdr5 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >3 publications with Wdr5 and Necrosis
 Neoplasms Antibodies  >2 publications with Wdr5 and Neoplasms
 Drug Toxicity Antibodies  >1 publications with Wdr5 and Drug Toxicity
 Kidney Diseases Antibodies  >1 publications with Wdr5 and Kidney Diseases
 Pancreatic Neoplasms Antibodies  >1 publications with Wdr5 and Pancreatic Neoplasms
 Fibrosis Antibodies  >1 publications with Wdr5 and Fibrosis
 Carcinoma Antibodies  >1 publications with Wdr5 and Carcinoma
 Congenital Abnormalities Antibodies  >1 publications with Wdr5 and Congenital Abnormalities
 Adenocarcinoma Antibodies  >1 publications with Wdr5 and Adenocarcinoma
 Genomic Instability Antibodies  >1 publications with Wdr5 and Genomic Instability

Organs/Tissues associated with anti-Wdr5 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >9 publications with Wdr5 and Bone
 Embryonic Tissue Antibodies  >5 publications with Wdr5 and Embryonic Tissue
 Muscle Antibodies  >3 publications with Wdr5 and Muscle
 Bone Marrow Antibodies  >2 publications with Wdr5 and Bone Marrow
 Spleen Antibodies  >1 publications with Wdr5 and Spleen
 Thyroid Antibodies  >1 publications with Wdr5 and Thyroid
 Kidney Antibodies  >1 publications with Wdr5 and Kidney
 Testis Antibodies  >1 publications with Wdr5 and Testis
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