Rabbit Anti-ZC3H8 Polyclonal Antibody – Cat# MBS6364851

ZC3H8 Antibody – Rabbit Polyclonal

Name: ZC3H8 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6364851
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6364851

Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Induces… More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ZC3H8, Polyclonal Antibody

Full Product Name

ZC3H8, NT (ZC3H8, ZC3HDC8, Zinc finger CCCH domain-containing protein 8) (MaxLight 750)

Product Gene Name

anti-ZC3H8 antibody

Product Synonym Names

ZC3H8; ZC3HDC8; Zinc finger CCCH domain-containing protein 8

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

33,576 Da

Chromosome Location

Chromosome: 2; NC_000002.11 (112973439..113012664, complement). Location: 2q13

3D Structure

ModBase 3D Structure for Q8N5P1

Immunogen

ZC3H8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-90 amino acids from the N-terminal region of human ZC3H8.

Conjugate

MaxLight750

Note

Preservative Free

Product Categories/Family for anti-ZC3H8 antibody

Antibodies; Transcription Factors; Zinc (Ring) Finger

Applications Tested/Suitable for anti-ZC3H8 antibody

Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)

Application Notes for anti-ZC3H8 antibody

FC/FACS: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-ZC3H8 antibody

Lamesch, P., et al. Genomics 89(3):307-315(2007). Hwang, E.S., et al. Immunology 106(4):464-469(2002). Hwang, E.S., et al. J. Immunol. 169(1):248-253(2002).

Other Notes

Small volumes of anti-ZC3H8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ZC3H8 purchase

MBS6364851 is an antibody targeting ZC3H8. Also known as ZC3H8, NT (ZC3H8, ZC3HDC8, Zinc finger CCCH domain-containing protein 8) (MaxLight 750). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ZC3H8. It may not necessarily be applicable to this product.

NCBI GI #

217416362

NCBI GeneID

84524

NCBI Accession #

NP_115883.2

UniProt Primary Accession #

Q8N5P1

UniProt Secondary Accession #

Q9BZ75

UniProt Related Accession #

Q8N5P1

GenBank Nucleotide #

NM_032494.2

NCBI Official Full Name

zinc finger CCCH domain-containing protein 8

NCBI Official Synonym Full Names

zinc finger CCCH-type containing 8

NCBI Official Symbol

ZC3H8

NCBI Official Synonym Symbols

Fliz1; ZC3HDC8

UniProt Protein Name

Zinc finger CCCH domain-containing protein 8

Protein Family

Zinc finger CCCH domain-containing protein

UniProt Gene Name

ZC3H8

UniProt Synonym Gene Names

ZC3HDC8

UniProt Entry Name

ZC3H8_HUMAN

NCBI Protein Information

zinc finger CCCH domain-containing protein 8; zinc finger CCCH type domain containing 8; zinc finger CCCH-type domain containing 8

UniProt Comments for ZC3H8

ZC3H8: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 2q13

Cellular Component: Cajal body; transcription elongation factor complex; nucleus

Molecular Function: protein binding; sequence-specific DNA binding; metal ion binding; transcription factor activity

Biological Process: response to antibiotic; apoptosis; snRNA transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; T cell homeostasis; negative regulation of T cell differentiation in the thymus; negative regulation of transcription, DNA-dependent; snRNA transcription from RNA polymerase III promoter

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.