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AIMP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS175413

Description: Rabbit IgG polyclonal antibody for Aminoacyl tRNA synthase complex-interacting multifunctional protein 2(AIMP2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.Background: AIMP2, Aminoacyl tRNA synthetase complex-interacting multifunctional… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AIMP2/p38, Polyclonal Antibody
Full Product Name
Anti-AIMP2/p38 antibody
Product Gene Name
anti-AIMP2 antibody
Product Synonym Names
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Aimp2 antibody; AIMP2_HUMAN antibody; Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody; Aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antibody; ARS interacting multi functional protein 2 antibody; JTV 1 antibody; JTV 1 protein antibody; JTV1 antibody; Multisynthase complex auxiliary component p38 antibody; Multisynthetase complex auxiliary component p38 antibody; P38 antibody; PRO0992 antibody; Protein JTV 1 antibody; Protein JTV-1 antibody; tRNA SYNTHETASE COFACTOR p38 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
35,349 Da
OMIM
600859
3D Structure
ModBase 3D Structure for Q13155
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human AIMP2/p38 (298-320aa NVQRWMRSCENLAPFNTALKLLK), different from the related rat and mouse sequences by three amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-AIMP2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Western Blot (WB) of anti-AIMP2 antibody

Anti-AIMP2/p38 antibody, MBS175413, Western blotting
Lane 1: Rat Liver Tissue Lysate
Lane 2: Rat Lung Tissue Lysate
Lane 3: Rat Kidney Tissue Lysate
Lane 4: Rat Brain Tissue Lysate
Lane 5: Marker
Lane 6: JURKAT Cell Lysate
Lane 7: CEM Cell Lysate
Lane 8: HUT Cell Lysate
Lane 9: U93T Cell Lysate
Lane 10: U93T Cell Lysate
Rabbit Anti-AIMP2 Polyclonal Antibody – Cat# MBS175413

Immunohistochemistry (IHC) of anti-AIMP2 antibody

Anti-AIMP2/p38 antibody, MBS175413, IHC(P)
IHC(P): Human Rectal Cancer Tissue
Rabbit Anti-AIMP2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS175413

Other Notes

Small volumes of anti-AIMP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AIMP2 purchase

MBS175413 is an antibody targeting AIMP2. Also known as Anti-AIMP2/p38 antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AIMP2. It may not necessarily be applicable to this product.

NCBI GI #
12644405
NCBI GeneID
7965
NCBI Accession #
Q13155.2
UniProt Primary Accession #
Q13155
UniProt Secondary Accession #
Q75MR1; Q96CZ5; Q9P1L2
UniProt Related Accession #
Q13155
NCBI Official Full Name
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
NCBI Official Synonym Full Names
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
NCBI Official Symbol
AIMP2
NCBI Official Synonym Symbols
P38; JTV1; JTV-1; PRO0992
UniProt Protein Name
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
UniProt Synonym Protein Names
Multisynthase complex auxiliary component p38; Protein JTV-1
Protein Family
Aminoacyl tRNA synthase complex-interacting multifunctional protein
UniProt Gene Name
AIMP2
UniProt Synonym Gene Names
JTV1
UniProt Entry Name
AIMP2_HUMAN
NCBI Protein Information
aminoacyl tRNA synthase complex-interacting multifunctional protein 2; protein JTV-1; ARS-interacting multi-functional protein 2; multisynthase complex auxiliary component p38; multisynthetase complex auxiliary component p38

NCBI Summary for AIMP2

The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown. [provided by RefSeq, Jul 2008]
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UniProt Comments for AIMP2

JTV1: Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: membrane; cytosol; nucleus

Molecular Function: protein binding

Biological Process: negative regulation of cell proliferation; tRNA aminoacylation for protein translation; apoptosis; positive regulation of protein ubiquitination; gene expression
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Research Articles on AIMP2

1. These findings suggested that, although excessive accumulation of oxidative DNA damage was present in LSCs, the relatively decreased phosphorylation of p38 might help leukemic cells escape senescence and apoptosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AIMP2 antibody

 Reference Product  PubMed Publications
 AIMP1 antibody  >6 publications with AIMP2 and AIMP1
 PARK2 antibody  >5 publications with AIMP2 and PARK2
 AIMP3 antibody  >4 publications with AIMP2 and AIMP3
 MARS antibody  >2 publications with AIMP2 and MARS
 EPRS antibody  >2 publications with AIMP2 and EPRS
 IARS antibody  >1 publications with AIMP2 and IARS
 RARS antibody  >1 publications with AIMP2 and RARS
 DARS antibody  >1 publications with AIMP2 and DARS
 KARS antibody  >1 publications with AIMP2 and KARS

Pathways associated with anti-AIMP2 antibody

 Products by Pathway  Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Keap1-Nrf2 Pathway antibodies  Keap1-Nrf2 Pathway Diagram
 Osteoclast Signaling Pathway antibodies  Osteoclast Signaling Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram

Diseases associated with anti-AIMP2 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >5 publications with AIMP2 and Brain Diseases
 Necrosis Antibodies  >3 publications with AIMP2 and Necrosis
 Poisoning Antibodies  >1 publications with AIMP2 and Poisoning
 Adenocarcinoma Antibodies  >1 publications with AIMP2 and Adenocarcinoma
 Liver Diseases Antibodies  >1 publications with AIMP2 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with AIMP2 and Liver Neoplasms

Organs/Tissues associated with anti-AIMP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >7 publications with AIMP2 and Lung
 Brain Antibodies  >5 publications with AIMP2 and Brain
 Blood Antibodies  >2 publications with AIMP2 and Blood
 Stomach Antibodies  >1 publications with AIMP2 and Stomach
 Liver Antibodies  >1 publications with AIMP2 and Liver
 Intestine Antibodies  >1 publications with AIMP2 and Intestine
 Skin Antibodies  >1 publications with AIMP2 and Skin
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