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ALIX/PDCD6IP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9433540

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein… More details

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Product Overview

Online Datasheet in PDF
Product Name
ALIX/PDCD6IP, Polyclonal Antibody
Full Product Name
ALIX/PDCD6IP Polyclonal Antibody
Product Gene Name
anti-ALIX/PDCD6IP antibody
Product Synonym Gene Name
PDCD6IP
Product Synonym Names
PDCD6IP; AIP1; ALIX; DRIP4; HP95; programmed cell death 6-interacting protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 50% glycerol, pH7.4
Purity/Purification
Affinity purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
30,453 Da
OMIM
608074
3D Structure
ModBase 3D Structure for Q8WUM4
Immunogen
Recombinant fusion protein of human ALIX/ PDCD6IP (NP_037506.2).
Conjugation
Unconjugated

Product Categories/Family for anti-ALIX/PDCD6IP antibody

Total protein Ab
Applications Tested/Suitable for anti-ALIX/PDCD6IP antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ALIX/PDCD6IP antibody
WB: 1:200-1:2000
IHC: 1:50-1:200

Western Blot (WB) of anti-ALIX/PDCD6IP antibody

Western blot analysis of extracts of various cell lines, using ALIX/ PDCD6IP antibody.
Rabbit Anti-ALIX/PDCD6IP Polyclonal Antibody – Cat# MBS9433540

Immunohistochemistry (IHC) of anti-ALIX/PDCD6IP antibody

Immunohistochemistry of paraffin-embedded rat kidney using ALIX/ PDCD6IP antibody.
Rabbit Anti-ALIX/PDCD6IP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9433540

Immunohistochemistry (IHC) of anti-ALIX/PDCD6IP antibody

Immunohistochemistry of paraffin-embedded human prostate using ALIX/ PDCD6IP antibody.
Rabbit Anti-ALIX/PDCD6IP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9433540

Immunohistochemistry (IHC) of anti-ALIX/PDCD6IP antibody

Immunohistochemistry of paraffin-embedded human stomach using ALIX/ PDCD6IP antibody.
Rabbit Anti-ALIX/PDCD6IP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9433540

Other Notes

Small volumes of anti-ALIX/PDCD6IP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALIX/PDCD6IP purchase

MBS9433540 is an antibody targeting ALIX/PDCD6IP. Also known as ALIX/PDCD6IP Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALIX/PDCD6IP. It may not necessarily be applicable to this product.

NCBI GI #
22027538
NCBI GeneID
10015
NCBI Accession #
NP_037506.2
UniProt Primary Accession #
Q8WUM4
UniProt Secondary Accession #
Q6NUS1; Q9BX86; Q9NUN0; Q9P2H2; Q9UKL5; C5MQH7; E9PFU1
UniProt Related Accession #
Q8WUM4
GenBank Nucleotide #
NM_013374.5
NCBI Official Full Name
programmed cell death 6-interacting protein isoform 1
NCBI Official Synonym Full Names
programmed cell death 6 interacting protein
NCBI Official Symbol
PDCD6IP
NCBI Official Synonym Symbols
AIP1; ALIX; HP95; DRIP4
UniProt Protein Name
Programmed cell death 6-interacting protein
UniProt Synonym Protein Names
ALG-2-interacting protein 1; ALG-2-interacting protein X; Hp95
UniProt Gene Name
PDCD6IP
UniProt Synonym Gene Names
AIP1; ALIX; KIAA1375; PDCD6-interacting protein
UniProt Entry Name
PDC6I_HUMAN
NCBI Protein Information
programmed cell death 6-interacting protein

UniProt Comments for ALIX/PDCD6IP

Alix: an adaptor protein that may regulate the function of receptor and cytoskeleton-associated tyrosine kinases. A class E vacuolar protein sorting (VPS) factor involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. Fusion between endosomes and the vacuole will then target the cargo proteins to the vacuolar lumen. In case of infection, the HIV-1 virus directly takes advantage of its function for viral exocytosis and budding, via its interaction with HIV-1 p6 protein. May play a role in the regulation of both apoptosis and cell proliferation.

Protein type: Apoptosis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: focal adhesion; membrane; cytoplasm; melanosome; microtubule organizing center; immunological synapse; cytosol; vesicle

Molecular Function: protein binding; protein homodimerization activity; proteinase activated receptor binding; SH3 domain binding; calcium-dependent protein binding

Biological Process: protein transport; cell separation during cytokinesis; viral reproduction; apoptosis; viral infectious cycle; mitotic metaphase plate congression; nuclear organization and biogenesis
Show more

Research Articles on ALIX/PDCD6IP

1. Accordingly, ALIX depletion leads to furrow regression in cells with chromosome bridges, a phenotype associated with abscission checkpoint signaling failure.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALIX/PDCD6IP antibody

 Reference Product  PubMed Publications
 TSG101 antibody  >39 publications with ALIX/PDCD6IP and TSG101
 PDCD6 antibody  >18 publications with ALIX/PDCD6IP and PDCD6
 CHMP4B antibody  >14 publications with ALIX/PDCD6IP and CHMP4B
 CEP55 antibody  >10 publications with ALIX/PDCD6IP and CEP55
 CHMP4A antibody  >7 publications with ALIX/PDCD6IP and CHMP4A
 SH3GL2 antibody  >4 publications with ALIX/PDCD6IP and SH3GL2
 SH3KBP1 antibody  >3 publications with ALIX/PDCD6IP and SH3KBP1
 CHMP4C antibody  >2 publications with ALIX/PDCD6IP and CHMP4C
 ALG2 antibody  >1 publications with ALIX/PDCD6IP and ALG2

Pathways associated with anti-ALIX/PDCD6IP antibody

 Products by Pathway  Pathway Diagram
 Budding And Maturation Of HIV Virion Pathway antibodies  Budding And Maturation Of HIV Virion Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 Infectious Disease Pathway antibodies  Infectious Disease Pathway Diagram
 Late Phase Of HIV Life Cycle Pathway antibodies  Late Phase Of HIV Life Cycle Pathway Diagram
 Uptake And Actions Of Bacterial Toxins Pathway antibodies  Uptake And Actions Of Bacterial Toxins Pathway Diagram
 Uptake And Function Of Anthrax Toxins Pathway antibodies  Uptake And Function Of Anthrax Toxins Pathway Diagram

Diseases associated with anti-ALIX/PDCD6IP antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >4 publications with ALIX/PDCD6IP and Adenocarcinoma
 Kidney Diseases Antibodies  >4 publications with ALIX/PDCD6IP and Kidney Diseases
 Disease Models, Animal Antibodies  >3 publications with ALIX/PDCD6IP and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >2 publications with ALIX/PDCD6IP and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with ALIX/PDCD6IP and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with ALIX/PDCD6IP and Liver Diseases
 Anoxia Antibodies  >1 publications with ALIX/PDCD6IP and Anoxia
 Prostatic Diseases Antibodies  >1 publications with ALIX/PDCD6IP and Prostatic Diseases
 Breast Neoplasms Antibodies  >1 publications with ALIX/PDCD6IP and Breast Neoplasms
 Edema Antibodies  >1 publications with ALIX/PDCD6IP and Edema

Organs/Tissues associated with anti-ALIX/PDCD6IP antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with ALIX/PDCD6IP and Brain
 Kidney Antibodies  >10 publications with ALIX/PDCD6IP and Kidney
 Blood Antibodies  >7 publications with ALIX/PDCD6IP and Blood
 Nerve Antibodies  >5 publications with ALIX/PDCD6IP and Nerve
 Muscle Antibodies  >4 publications with ALIX/PDCD6IP and Muscle
 Lung Antibodies  >4 publications with ALIX/PDCD6IP and Lung
 Heart Antibodies  >2 publications with ALIX/PDCD6IP and Heart
 Liver Antibodies  >2 publications with ALIX/PDCD6IP and Liver
 Intestine Antibodies  >2 publications with ALIX/PDCD6IP and Intestine
 Pancreas Antibodies  >1 publications with ALIX/PDCD6IP and Pancreas
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