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Arginase (ARG) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2005127
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MBS2005127 is an antibody targeting ARG. Also known as Polyclonal Antibody to Arginase (ARG). Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Arginase (ARG), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Arginase (ARG)
Product Gene Name
anti-ARG antibody
Immunogen Sequence
Antigen: The target protein is fused with a His-tag and its sequence is listed below.
MGHHHHHHSG SEF-MSAKSR TIGI IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KEQECDVKDY GDLPFADIPN DSPFQIVKNP RSVGKASEQL AGKVAEVKKN GRISLVLGGD HSLAIGSISG HARVHPDLGV IWVDAHTDIN TPLTTTSGNL HGQPVSFLLK ELKGKIPDVP GFSWVTPCIS AKDIVYIGLR DVDPGEHYIL KTLGIKYFSM TEVDRLGIGK VMEETLSYLL GRKKRPIHLS FDVDGLDPSF TPATGTPVVG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTAVAIT LACFGLAREG NHKPIDYLNP PK
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against ARG. It has been selected for its ability to recognize ARG in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: ARG (MBS2005127)
Biotin Conjugated Antibody: ARG (MBS2001835)
Matching Pairs
Unconjugated Antibody: ARG (MBS2005127)
Immunogen: ARG (MBS2009183)
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Molecular Weight
25,356 Da
OMIM
M14502 mRNA
3D Structure
ModBase 3D Structure for P05089
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant Arg (Met1~Lys322) expressed in E.coli.
Cross Reactivity
Human, Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2051724
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-ARG antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-ARG antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-ARG antibody

Western Blot: Sample: Lane1: Human Liver Tissue; Lane2: Mouse Liver Tissue; Lane3: Mouse Heart Tissue.
Rabbit Anti-ARG Polyclonal Antibody – Cat# MBS2005127

Western Blot (WB) of anti-ARG antibody

Western Blot: Sample: Recombinant ARG, Human.
Rabbit Anti-ARG Polyclonal Antibody, Western Blot (WB) – Cat# MBS2005127

Immunohistochemistry (IHC) of anti-ARG antibody

DAB staining on IHC-P; Samples: Human Liver Tissue
Rabbit Anti-ARG Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2005127

Immunohistochemistry (IHC) of anti-ARG antibody

DAB staining on IHC-P; Samples: Human Liver Tissue)
Rabbit Anti-ARG Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2005127

Other Notes

Small volumes of anti-ARG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ARG. It may not necessarily be applicable to this product.

NCBI GI #
10947139
NCBI GeneID
383
NCBI Accession #
NP_000036.2
UniProt Primary Accession #
P05089
UniProt Secondary Accession #
Q5JWT5; Q5JWT6; Q8TE72; Q9BS50; A6NEA0
UniProt Related Accession #
P05089
GenBank Nucleotide #
NM_000045.3
NCBI Official Full Name
arginase-1 isoform 2
NCBI Official Synonym Full Names
arginase 1
NCBI Official Symbol
ARG1
UniProt Protein Name
Arginase-1
UniProt Synonym Protein Names
Liver-type arginase; Type I arginase
UniProt Gene Name
ARG1
NCBI Protein Information
arginase-1

NCBI Summary for ARG

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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UniProt Comments for ARG

ARG1: Homotrimer. By arginine or homoarginine. Belongs to the arginase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - arginine and proline; EC 3.5.3.1; Hydrolase

Chromosomal Location of Human Ortholog: 6q23.2

Cellular Component: cell soma; cytoplasm; cytosol; extracellular region; extracellular space; mitochondrial outer membrane; neuron projection; nucleus

Molecular Function: arginase activity; manganese ion binding

Biological Process: aging; arginine catabolic process; arginine catabolic process to ornithine; collagen biosynthetic process; defense response to protozoan; liver development; lung development; mammary gland involution; maternal process involved in female pregnancy; negative regulation of activated T cell proliferation; negative regulation of T cell proliferation; neutrophil degranulation; positive regulation of endothelial cell proliferation; response to amine; response to amino acid; response to axon injury; response to cadmium ion; response to drug; response to herbicide; response to manganese ion; response to methylmercury; response to selenium ion; response to vitamin A; response to vitamin E; response to zinc ion; urea cycle

Disease: Argininemia
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Research Articles on ARG

1. The data in this study suggest that arginase I inhibition potentially represents a novel therapeutic target for the prevention and/or treatment of bronchopulmonary dysplasia-associated pulmonary hypertension.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ARG antibody

 Reference Product  PubMed Publications
 ARG2 antibody  >28 publications with ARG and ARG2
 NOS1 antibody  >5 publications with ARG and NOS1

Pathways associated with anti-ARG antibody

 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram

Diseases associated with anti-ARG antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >62 publications with ARG and Inflammation
 Neoplasms Antibodies  >59 publications with ARG and Neoplasms
 Disease Models, Animal Antibodies  >36 publications with ARG and Disease Models, Animal
 Nervous System Diseases Antibodies  >35 publications with ARG and Nervous System Diseases
 Immune System Diseases Antibodies  >31 publications with ARG and Immune System Diseases
 Necrosis Antibodies  >22 publications with ARG and Necrosis
 Pain Antibodies  >20 publications with ARG and Pain
 Cardiovascular Diseases Antibodies  >20 publications with ARG and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >20 publications with ARG and Lung Neoplasms
 Asthma Antibodies  >19 publications with ARG and Asthma

Organs/Tissues associated with anti-ARG antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >151 publications with ARG and Blood
 Muscle Antibodies  >99 publications with ARG and Muscle
 Brain Antibodies  >69 publications with ARG and Brain
 Lung Antibodies  >65 publications with ARG and Lung
 Liver Antibodies  >43 publications with ARG and Liver
 Eye Antibodies  >25 publications with ARG and Eye
 Bone Marrow Antibodies  >19 publications with ARG and Bone Marrow
 Spleen Antibodies  >15 publications with ARG and Spleen
 Skin Antibodies  >12 publications with ARG and Skin
 Uterus Antibodies  >9 publications with ARG and Uterus
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