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ATIC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4150463

This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP… More details

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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ATIC, Polyclonal Antibody
Full Product Name
Anti-ATIC Antibody
Product Gene Name
anti-ATIC antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Specificity
Western blot analysis of extracts of various cell lines, using ATIC antibody. Immunohistochemistry of paraffin-embedded human esophagus using ATIC antibody at dilution of 1:200 (400x lens). Immunohistochemistry of paraffin-embedded human thyroid cancer using ATIC antibody at dilution of 1:200 (400x lens). Immunofluorescence analysis of U20S cell using ATIC antibody. Blue: DAPI for nuclear staining.
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
64,524 Da
OMIM
U37436 mRNA
Immunogen
Recombinant protein of human ATIC
Storage Buffer
PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Applications Tested/Suitable for anti-ATIC antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-ATIC antibody
WB: 1:500 - 1:2000
IHC: 1:50- 1:200
IF: 1:50- 1:200

Western Blot (WB) of anti-ATIC antibody

Rabbit Anti-ATIC Polyclonal Antibody – Cat# MBS4150463

Immunohistochemistry (IHC) of anti-ATIC antibody

Rabbit Anti-ATIC Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS4150463

Immunohistochemistry (IHC) of anti-ATIC antibody

Rabbit Anti-ATIC Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS4150463

Immunofluorescence (IF) of anti-ATIC antibody

Rabbit Anti-ATIC Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS4150463

Other Notes

Small volumes of anti-ATIC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATIC purchase

MBS4150463 is an antibody targeting ATIC. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ATIC. It may not necessarily be applicable to this product.

NCBI GI #
823670596
NCBI GeneID
471
NCBI Accession #
AKI70509.1
UniProt Secondary Accession #
Q13856; Q53S28; A8K202; E9PBU3
UniProt Related Accession #
P31939
NCBI Official Full Name
ATIC, partial
NCBI Official Synonym Full Names
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
NCBI Official Symbol
ATIC
NCBI Official Synonym Symbols
PURH; AICAR; AICARFT; IMPCHASE; HEL-S-70p
UniProt Protein Name
Bifunctional purine biosynthesis protein PURH
UniProt Synonym Protein Names
Bifunctional purine biosynthesis protein PURH, N-terminally processed
UniProt Gene Name
ATIC
UniProt Synonym Gene Names
PURH
NCBI Protein Information
bifunctional purine biosynthesis protein PURH

UniProt Comments for ATIC

ATIC: Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. Defects in ATIC are the cause of AICAR transformylase/IMP cyclohydrolase deficiency (AICAR). A neurologically devastating inborn error of purine biosynthesis. Patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA- ribotide and its derivatives in erythrocytes and fibroblasts. AICAR causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness. Belongs to the PurH family.

Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.3; EC 3.5.4.10; Hydrolase; Methyltransferase; Mitochondrial; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: cell-cell adherens junction; cytosol; membrane

Molecular Function: IMP cyclohydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity; protein homodimerization activity

Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine ribonucleoside monophosphate biosynthetic process

Disease: Aicar Transformylase/imp Cyclohydrolase Deficiency
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Research Articles on ATIC

1. ATIC 347C>G gene polymorphism may be associated with the development of MTX induced gastrointestinal adverse events.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ATIC antibody

 Reference Product  PubMed Publications
 MTHFD1 antibody  >6 publications with ATIC and MTHFD1
 GART antibody  >6 publications with ATIC and GART
 ADSL antibody  >5 publications with ATIC and ADSL
 SHMT1 antibody  >4 publications with ATIC and SHMT1
 ADSS antibody  >2 publications with ATIC and ADSS
 PAICS antibody  >2 publications with ATIC and PAICS
 PPAT antibody  >1 publications with ATIC and PPAT
 SHMT2 antibody  >1 publications with ATIC and SHMT2
 PFAS antibody  >1 publications with ATIC and PFAS

Pathways associated with anti-ATIC antibody

 Products by Pathway  Pathway Diagram
 Inosine Monophosphate Biosynthesis, PRPP + Glutamine => IMP Pathway antibodies  Inosine Monophosphate Biosynthesis, PRPP + Glutamine => IMP Pathway Diagram
 Inosine Monophosphate Biosynthesis, PRPP + Glutamine => IMP Pathway antibodies  Inosine Monophosphate Biosynthesis, PRPP + Glutamine => IMP Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram

Diseases associated with anti-ATIC antibody

 Disease Name  Pubmed Publications
 Arthritis, Rheumatoid Antibodies  >23 publications with ATIC and Arthritis, Rheumatoid
 Kidney Diseases Antibodies  >12 publications with ATIC and Kidney Diseases
 Carcinoma Antibodies  >10 publications with ATIC and Carcinoma
 Neoplasms, Experimental Antibodies  >10 publications with ATIC and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >9 publications with ATIC and Cardiovascular Diseases
 Renal Insufficiency Antibodies  >6 publications with ATIC and Renal Insufficiency
 Inflammation Antibodies  >4 publications with ATIC and Inflammation
 Lung Diseases Antibodies  >4 publications with ATIC and Lung Diseases
 Liver Diseases Antibodies  >4 publications with ATIC and Liver Diseases
 Hypertension Antibodies  >3 publications with ATIC and Hypertension

Organs/Tissues associated with anti-ATIC antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >32 publications with ATIC and Blood
 Liver Antibodies  >22 publications with ATIC and Liver
 Kidney Antibodies  >17 publications with ATIC and Kidney
 Vascular Antibodies  >12 publications with ATIC and Vascular
 Bone Antibodies  >9 publications with ATIC and Bone
 Lung Antibodies  >8 publications with ATIC and Lung
 Skin Antibodies  >6 publications with ATIC and Skin
 Muscle Antibodies  >5 publications with ATIC and Muscle
 Brain Antibodies  >5 publications with ATIC and Brain
 Ovary Antibodies  >4 publications with ATIC and Ovary
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