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ATP6V0A2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8527160

Rabbit polyclonal ATP6V0A2 (1) antibody was raised against a recombinate human ATP6V0A2 protein 2-199aa (BC068531). More details

$430 / 0.1 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ATP6V0A2, Polyclonal Antibody
Full Product Name
ATP6V0A2 Antibody
Product Gene Name
anti-ATP6V0A2 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Reacts with: Human
Predicted: Rat, Mouse
Not yet tested in other species.
Form/Format
Lyophilized ATP6V0A2 antibody purified by protein affinity column containing 1% BSA and 0.02% NaN3
Purity/Purification
ATP6V0A2 antibody purified by protein affinity column containing 1% BSA and 0.02% NaN3
Preparation and Storage
Dilution instruction and storage: Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Molecular Weight
98,082 Da
OMIM
219200
Host Note
Rabbit polyclonal ATP6V0A2 (1) antibody was raised against a recombinate human ATP6V0A2 protein 2-199aa.
Source
Rabbit polyclonal ATP6V0A2 antibody was raised against a recombinant human ATP6V0A2 protein 2-199aa (BC068531).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ATP6V0A2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ATP6V0A2 antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:200-1:1,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user

Western Blot (WB) of anti-ATP6V0A2 antibody

Rabbit Anti-ATP6V0A2 Polyclonal Antibody – Cat# MBS8527160

Immunohistochemistry (IHC) of anti-ATP6V0A2 antibody

Rabbit Anti-ATP6V0A2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS8527160

Product References and Citations for anti-ATP6V0A2 antibody

(1) Fischer, B., Dimopoulou, A., Egerer, J., et al. Further characterization of ATP6V0A2-related autosomal recessive cutis laxa. Hum. Genet. 131 (11), 1761-1773 (2012).

Other Notes

Small volumes of anti-ATP6V0A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATP6V0A2 purchase

MBS8527160 is an antibody targeting ATP6V0A2. Also known as ATP6V0A2 Antibody. Reactive in Reacts with: Human
Predicted: Rat, Mouse
Not yet tested in other species.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ATP6V0A2. It may not necessarily be applicable to this product.

NCBI GI #
18490157
NCBI GeneID
23545
NCBI Accession #
AAH22300.1
UniProt Secondary Accession #
Q6NUM0; A8K026
UniProt Related Accession #
Q9Y487
NCBI Official Full Name
ATP6V0A2 protein
NCBI Official Synonym Full Names
ATPase H+ transporting V0 subunit a2
NCBI Official Symbol
ATP6V0A2
NCBI Official Synonym Symbols
A2; RTF; TJ6; WSS; ARCL; J6B7; STV1; TJ6M; TJ6S; VPH1; ARCL2A; ATP6A2; ATP6N1D
UniProt Protein Name
V-type proton ATPase 116 kDa subunit a isoform 2
UniProt Synonym Protein Names
Lysosomal H(+)-transporting ATPase V0 subunit a2; TJ6; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2
Protein Family
V-type proton ATPase
UniProt Gene Name
ATP6V0A2
UniProt Synonym Gene Names
V-ATPase 116 kDa isoform a2
NCBI Protein Information
V-type proton ATPase 116 kDa subunit a isoform 2; V-type proton ATPase 116 kDa subunit a

NCBI Summary for ATP6V0A2

The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009]
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UniProt Comments for ATP6V0A2

Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633).
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Research Articles on ATP6V0A2

1. In cisplatin resistant cells, shRNA mediated inhibition of V-ATPase-V0a2 enhanced sensitivity towards both cisplatin and carboplatin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ATP6V0A2 antibody

 Reference Product  PubMed Publications
 ATP6V1E2 antibody  >1 publications with ATP6V0A2 and ATP6V1E2
 ATP6V0D2 antibody  >1 publications with ATP6V0A2 and ATP6V0D2
 ATP6V0D1 antibody  >1 publications with ATP6V0A2 and ATP6V0D1
 ATP6V1B1 antibody  >1 publications with ATP6V0A2 and ATP6V1B1

Pathways associated with anti-ATP6V0A2 antibody

 Products by Pathway  Pathway Diagram
 Collecting Duct Acid Secretion Pathway antibodies  Collecting Duct Acid Secretion Pathway Diagram
 Collecting Duct Acid Secretion Pathway antibodies  Collecting Duct Acid Secretion Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Insulin Receptor Recycling Pathway antibodies  Insulin Receptor Recycling Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway antibodies  Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram

Diseases associated with anti-ATP6V0A2 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >8 publications with ATP6V0A2 and Congenital Abnormalities
 Wrinkly skin syndrome Antibodies  >6 publications with ATP6V0A2 and Wrinkly skin syndrome
 Neurobehavioral Manifestations Antibodies  >2 publications with ATP6V0A2 and Neurobehavioral Manifestations
 Inflammation Antibodies  >2 publications with ATP6V0A2 and Inflammation
 Abnormalities, Multiple Antibodies  >2 publications with ATP6V0A2 and Abnormalities, Multiple
 Fetal Death Antibodies  >1 publications with ATP6V0A2 and Fetal Death
 Mental Disorders Antibodies  >1 publications with ATP6V0A2 and Mental Disorders
 Infertility, Male Antibodies  >1 publications with ATP6V0A2 and Infertility, Male
 Movement Disorders Antibodies  >1 publications with ATP6V0A2 and Movement Disorders
 Necrosis Antibodies  >1 publications with ATP6V0A2 and Necrosis

Organs/Tissues associated with anti-ATP6V0A2 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >14 publications with ATP6V0A2 and Skin
 Bone Antibodies  >6 publications with ATP6V0A2 and Bone
 Blood Antibodies  >6 publications with ATP6V0A2 and Blood
 Placenta Antibodies  >5 publications with ATP6V0A2 and Placenta
 Uterus Antibodies  >5 publications with ATP6V0A2 and Uterus
 Connective Tissue Antibodies  >3 publications with ATP6V0A2 and Connective Tissue
 Embryonic Tissue Antibodies  >2 publications with ATP6V0A2 and Embryonic Tissue
 Brain Antibodies  >2 publications with ATP6V0A2 and Brain
 Adipose Tissue Antibodies  >1 publications with ATP6V0A2 and Adipose Tissue
 Liver Antibodies  >1 publications with ATP6V0A2 and Liver
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