BMPR1B Antibody – Rabbit Polyclonal

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

BMPR1B: a kinase of the STKR family. A type I cell-surface receptor for bone morphogenetic protein. Expressed at ighest level in the prostate. May be upregulated by androgen stimulation in cells which expresses the androgen receptor.

Protein type: Protein kinase, TKL; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 4q22-q24

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: protein serine/threonine kinase activity; protein binding; transforming growth factor beta receptor activity, type I; metal ion binding; SMAD binding; ATP binding; transmembrane receptor protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: chondrocyte development; positive regulation of bone mineralization; protein amino acid phosphorylation; limb morphogenesis; BMP signaling pathway; positive regulation of osteoblast differentiation; ovulation cycle; eye development; dorsal/ventral pattern formation; retina development in camera-type eye; proteoglycan biosynthetic process; ovarian cumulus expansion; inflammatory response; positive regulation of cell differentiation; skeletal development; cartilage condensation; retinal ganglion cell axon guidance

Disease: Chondrodysplasia, Acromesomelic, With Genital Anomalies; Brachydactyly, Type A2