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BTC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS126358
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The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BTC, Polyclonal Antibody
Full Product Name
BTC Polyclonal Antibody
Product Gene Name
anti-BTC antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
178
OMIM
600345
3D Structure
ModBase 3D Structure for P35070
Species
Human
Immunogen
Recombinant protein of human BTC
Calculated Molecular Weight
20kDa

Product Categories/Family for anti-BTC antibody

Polyclonal
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-BTC antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-BTC antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200

Western Blot (WB) of anti-BTC antibody

Western blot analysis of extracts of various cell lines, using BTC antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Rabbit Anti-BTC Polyclonal Antibody – Cat# MBS126358

Other Notes

Small volumes of anti-BTC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BTC purchase

MBS126358 is an antibody targeting BTC. Also known as BTC Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BTC. It may not necessarily be applicable to this product.

NCBI GI #
461653
NCBI GeneID
685
NCBI Accession #
P35070.1
UniProt Primary Accession #
P35070
UniProt Secondary Accession #
Q96F48
UniProt Related Accession #
P35070
NCBI Official Full Name
Probetacellulin
NCBI Official Synonym Full Names
betacellulin
NCBI Official Symbol
BTC
UniProt Protein Name
Probetacellulin
Protein Family
Probetacellulin
UniProt Gene Name
BTC
UniProt Synonym Gene Names
BTC
UniProt Entry Name
BTC_HUMAN
NCBI Protein Information
probetacellulin

UniProt Comments for BTC

BTC: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Protein type: Membrane protein, integral; Cell cycle regulation; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; integral to membrane; plasma membrane; extracellular region

Molecular Function: protein binding; growth factor activity; epidermal growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of fibroblast proliferation; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of mitosis; positive regulation of cell proliferation; innate immune response; positive regulation of cell differentiation; negative regulation of apoptosis
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Research Articles on BTC

1. CXCL8 production from lung cancer cells could be initiated by an autocrine mechanism or external sources of BTC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BTC antibody

 Reference Product  PubMed Publications
 EGFR antibody  >88 publications with BTC and EGFR
 ERBB2 antibody  >58 publications with BTC and ERBB2
 ERBB4 antibody  >52 publications with BTC and ERBB4
 EREG antibody  >47 publications with BTC and EREG
 HBEGF antibody  >47 publications with BTC and HBEGF
 INS antibody  >9 publications with BTC and INS
 NRG1 antibody  >9 publications with BTC and NRG1
 NRG2 antibody  >6 publications with BTC and NRG2
 NRG4 antibody  >2 publications with BTC and NRG4

Pathways associated with anti-BTC antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 ErbB Receptor Signaling Network Pathway antibodies  ErbB Receptor Signaling Network Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram

Diseases associated with anti-BTC antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >37 publications with BTC and Disease Models, Animal
 Liver Neoplasms Antibodies  >31 publications with BTC and Liver Neoplasms
 Liver Diseases Antibodies  >27 publications with BTC and Liver Diseases
 Necrosis Antibodies  >20 publications with BTC and Necrosis
 Anemia Antibodies  >16 publications with BTC and Anemia
 Carcinoma, Hepatocellular Antibodies  >14 publications with BTC and Carcinoma, Hepatocellular
 Inflammation Antibodies  >12 publications with BTC and Inflammation
 Neoplasm Metastasis Antibodies  >10 publications with BTC and Neoplasm Metastasis
 Urinary Bladder Neoplasms Antibodies  >8 publications with BTC and Urinary Bladder Neoplasms
 Brain Diseases Antibodies  >7 publications with BTC and Brain Diseases

Organs/Tissues associated with anti-BTC antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >72 publications with BTC and Liver
 Ovary Antibodies  >33 publications with BTC and Ovary
 Brain Antibodies  >19 publications with BTC and Brain
 Kidney Antibodies  >17 publications with BTC and Kidney
 Prostate Antibodies  >12 publications with BTC and Prostate
 Connective Tissue Antibodies  >6 publications with BTC and Connective Tissue
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