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C-JUN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629001

The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus.… More details

$510 / 0.05 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
c-Jun, Polyclonal Antibody
Full Product Name
c-Jun, phosphorylated (Tyr170) (Transcription Factor AP-1, Activator Protein 1, AP1, Proto-oncogene c-Jun, V-jun Avian Sarcoma Virus 17 Oncogene Homolog, p39, JUN)
Product Gene Name
anti-C-JUN antibody
Product Synonym Names
Anti -c-Jun, phosphorylated (Tyr170) (Transcription Factor AP-1, Activator Protein 1, AP1, Proto-oncogene c-Jun, V-jun Avian Sarcoma Virus 17 Oncogene Homolog, p39, JUN)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human c-Jun when phosphorylated at tyrosine 170. Species Cross-Reactivity: mouse, rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
35,629 Da
Chromosome Location
Chromosome: 6; NC_010448.2 (141029845..141031055)
3D Structure
ModBase 3D Structure for P56432
Immunogen
Synthetic phosphopeptide corresponding to human c-Jun around the phosphorylation site of tyrosine 170 (P-V-YP-A-N).

Product Categories/Family for anti-C-JUN antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-C-JUN antibody
Western Blot (WB)
Application Notes for anti-C-JUN antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 1:500-1:1,000

Western Blot (WB) of anti-C-JUN antibody

Western blot analysis of c-Jun (Tyr170) in HeLa cells.
Rabbit Anti-C-JUN Polyclonal Antibody – Cat# MBS629001

Other Notes

Small volumes of anti-C-JUN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C-JUN purchase

MBS629001 is an antibody targeting C-JUN. Also known as c-Jun, phosphorylated (Tyr170) (Transcription Factor AP-1, Activator Protein 1, AP1, Proto-oncogene c-Jun, V-jun Avian Sarcoma Virus 17 Oncogene Homolog, p39, JUN). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for C-JUN. It may not necessarily be applicable to this product.

NCBI GI #
1911701
NCBI GeneID
396913
UniProt Primary Accession #
P56432
UniProt Related Accession #
P56432
NCBI Official Full Name
c-Jun
NCBI Official Symbol
C-JUN
NCBI Official Synonym Symbols
Jun
UniProt Protein Name
Transcription factor AP-1
UniProt Synonym Protein Names
Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog
Protein Family
C-Jun-amino-terminal kinase-interacting protein
UniProt Gene Name
JUN
UniProt Entry Name
JUN_PIG
NCBI Protein Information
transcription factor AP-1; AP1; activator protein 1; proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog

UniProt Comments for C-JUN

Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.

Subunit structure: Heterodimer with either FOS or BATF3 or ATF7

By similarity. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with MYBBP1A, SP1, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with HIVEP3. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex

By similarity. Interacts with RNF187

Subcellular location: Nucleus

Post-translational modification: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC

Sequence similarities: Belongs to the bZIP family. Jun subfamily.Contains 1 bZIP domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-C-JUN antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram

Diseases associated with anti-C-JUN antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >3084 publications with C-JUN and Death
 Necrosis Antibodies  >2383 publications with C-JUN and Necrosis
 Nervous System Diseases Antibodies  >1241 publications with C-JUN and Nervous System Diseases
 Central Nervous System Diseases Antibodies  >946 publications with C-JUN and Central Nervous System Diseases
 Brain Diseases Antibodies  >936 publications with C-JUN and Brain Diseases
 Disease Models, Animal Antibodies  >913 publications with C-JUN and Disease Models, Animal
 Immune System Diseases Antibodies  >653 publications with C-JUN and Immune System Diseases
 Liver Diseases Antibodies  >645 publications with C-JUN and Liver Diseases
 Lung Diseases Antibodies  >467 publications with C-JUN and Lung Diseases
 Immunoproliferative Disorders Antibodies  >314 publications with C-JUN and Immunoproliferative Disorders

Organs/Tissues associated with anti-C-JUN antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2390 publications with C-JUN and Blood
 Brain Antibodies  >2268 publications with C-JUN and Brain
 Muscle Antibodies  >1453 publications with C-JUN and Muscle
 Lung Antibodies  >901 publications with C-JUN and Lung
 Heart Antibodies  >771 publications with C-JUN and Heart
 Skin Antibodies  >632 publications with C-JUN and Skin
 Embryonic Tissue Antibodies  >372 publications with C-JUN and Embryonic Tissue
 Intestine Antibodies  >251 publications with C-JUN and Intestine
 Joint Antibodies  >210 publications with C-JUN and Joint
 Stomach Antibodies  >143 publications with C-JUN and Stomach
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