Rabbit Anti-C8B Polyclonal Antibody – Cat# MBS9128596

Western blot analysis of extracts of various cell lines, using C8B antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.

C8B Antibody – Rabbit Polyclonal

Name: C8B Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9128596
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9128596

This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which… More details

$225 / 0.02 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

C8B, Polyclonal Antibody

Full Product Name

C8B Polyclonal Antibody

Product Gene Name

anti-C8B antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Purity/Purification

Affinity Purification

Preparation and Storage

Store at -20 degree C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

67kDa

OMIM

120960

3D Structure

ModBase 3D Structure for P07358

Immunogen

Recombinant protein of human C8B

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-C8B antibody

Western Blot (WB)

Application Notes for anti-C8B antibody

WB 1:500 - 1:2000

Other Notes

Small volumes of anti-C8B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C8B purchase

MBS9128596 is an antibody targeting C8B. Also known as C8B Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for C8B. It may not necessarily be applicable to this product.

NCBI GI #

514239916

NCBI GeneID

732

NCBI Accession #

NP_000057.2

UniProt Primary Accession #

P07358

UniProt Secondary Accession #

A1L4K7

UniProt Related Accession #

P07358

GenBank Nucleotide #

NM_000066.3

NCBI Official Full Name

complement component C8 beta chain isoform 1 preproprotein

NCBI Official Synonym Full Names

complement component 8, beta polypeptide

NCBI Official Symbol

C8B

NCBI Official Synonym Symbols

C82

UniProt Protein Name

Complement component C8 beta chain

UniProt Synonym Protein Names

Complement component 8 subunit beta

Protein Family

Complement component

UniProt Gene Name

C8B

UniProt Entry Name

CO8B_HUMAN

NCBI Protein Information

complement component C8 beta chain

UniProt Comments for C8B

C8B: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C8B are a cause of complement component 8 deficiency type 2 (C8D2). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p32.2

Cellular Component: membrane attack complex; extracellular space; membrane; extracellular region; vesicle

Molecular Function: protein complex binding

Biological Process: cytolysis; complement activation, alternative pathway; regulation of complement activation; innate immune response; immune response; complement activation, classical pathway; complement activation

Disease: Complement Component 8 Deficiency, Type Ii

Research Articles on C8B

1. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-C8B antibody

Products by Pathway	Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Complement Activation, Classical Pathway antibodies	Complement Activation, Classical Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Prion Diseases Pathway antibodies	Prion Diseases Pathway Diagram
Prion Diseases Pathway antibodies	Prion Diseases Pathway Diagram

Diseases associated with anti-C8B antibody

Disease Name	Pubmed Publications
Meningitis Antibodies	>4 publications with C8B and Meningitis
Inflammation Antibodies	>3 publications with C8B and Inflammation
Neisseriaceae Infections Antibodies	>3 publications with C8B and Neisseriaceae Infections
Disease Models, Animal Antibodies	>2 publications with C8B and Disease Models, Animal
Cell Transformation, Neoplastic Antibodies	>1 publications with C8B and Cell Transformation, Neoplastic
Brain Diseases Antibodies	>1 publications with C8B and Brain Diseases
Necrosis Antibodies	>1 publications with C8B and Necrosis

Organs/Tissues associated with anti-C8B antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>3 publications with C8B and Liver
Brain Antibodies	>1 publications with C8B and Brain
Lung Antibodies	>1 publications with C8B and Lung