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anti-CDKN1B antibody :: Rabbit CDKN1B Polyclonal Antibody

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Catalog # MBS125745 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
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  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $275 +1 FREE 8GB USB
  0.2 mL  /  $430 +1 FREE 8GB USB
Product Name

CDKN1B, Polyclonal Antibody

Popular Item
Full Product Name

CDKN1B Polyclonal Antibody

Product Synonym Names
CDKN1B; CDKN4; KIP1; MEN1B; MEN4; P27KIP1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 610755
3D Structure
ModBase 3D Structure for P46527
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Calculated MW
22kDa
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human CDKN1B (NP_004055.1)
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20°C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-CDKN1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CDKN1B antibody
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
Product Categories/Family for anti-CDKN1B antibody
Applications Tested/Suitable for anti-CDKN1B antibody
Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
Application Notes for anti-CDKN1B antibody
Western Blot (WB) 1:500 - 1:2000
Immunohistochemistry (IHC): 1:50-1:200
Immunofluorescence (IF)IF 1:20-1:50

Immunohistochemistry (IHC) of anti-CDKN1B antibody
Immunohistochemistry of paraffin-embedded rat brain using CDKN1B Antibody at dilution of 1:200 (40x lens).
anti-CDKN1B antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CDKN1B antibody
Immunohistochemistry of paraffin-embedded mouse kidney using CDKN1B Antibody at dilution of 1:200 (40x lens).
anti-CDKN1B antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-CDKN1B antibody
Immunohistochemistry of paraffin-embedded rat brain using CDKN1B Antibody at dilution of 1:100 (40x lens).
anti-CDKN1B antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-CDKN1B antibody
Immunofluosrescence analysis of Hela cells using CDKN1B antibody (MBS125745). Blue: DAPI for nuclear stainig.
anti-CDKN1B antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for CDKN1B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Cyclin-dependent kinase inhibitor 1B
NCBI Official Synonym Full Names
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
NCBI Official Symbol
CDKN1B  [Similar Products]
NCBI Official Synonym Symbols
KIP1; MEN4; CDKN4; MEN1B; P27KIP1
  [Similar Products]
NCBI Protein Information
cyclin-dependent kinase inhibitor 1B
UniProt Protein Name
Cyclin-dependent kinase inhibitor 1B
UniProt Synonym Protein Names
Cyclin-dependent kinase inhibitor p27; p27Kip1
UniProt Gene Name
CDKN1B  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
CDN1B_HUMAN
NCBI Summary for CDKN1B
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
UniProt Comments for CDKN1B
p27Kip1: a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. May mediate TGF beta-induced g1 arrest. Its degradation is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

Protein type: Inhibitor; Protein kinase, regulatory subunit; Oncoprotein; Cell cycle regulation

Chromosomal Location of Human Ortholog: 12p13.1-p12

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol; endosome

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; chaperone binding; protein complex binding; Hsp70 protein binding; caspase activator activity; protein phosphatase binding; transforming growth factor beta receptor, cytoplasmic mediator activity

Biological Process: response to peptide hormone stimulus; negative regulation of kinase activity; nerve growth factor receptor signaling pathway; positive regulation of microtubule polymerization; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; response to estradiol stimulus; negative regulation of cell proliferation; sensory perception of sound; positive regulation of cell proliferation; response to glucose stimulus; negative regulation of mitotic cell cycle; cell cycle arrest; inner ear development; potassium ion transport; response to drug; caspase activation; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cell motility; response to amino acid stimulus; response to cadmium ion; response to hypoxia; positive regulation of protein catabolic process; autophagic cell death; innate immune response; negative regulation of phosphorylation; negative regulation of cell growth; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; negative regulation of transcription, DNA-dependent; G1/S transition of mitotic cell cycle; negative regulation of apoptosis

Disease: Multiple Endocrine Neoplasia, Type Iv
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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