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CERK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2517893

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation. Catalyzes specifically the… More details

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Product Overview

Online Datasheet in PDF
Product Name
CERK, Polyclonal Antibody
Full Product Name
CERK Polyclonal Antibody
Product Gene Name
anti-CERK antibody
Product Synonym Names
LK4; hCERK; dA59H18.2; dA59H18.3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
1.5mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
37,781 Da
OMIM
610307
Immunogen
Recombinant protein of human CERK
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3

Product Categories/Family for anti-CERK antibody

Cell Biology
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CERK antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-CERK antibody
IHC: 1:25-1:100

Immunohistochemistry (IHC) of anti-CERK antibody

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CERK Polyclonal Antibody at dilution 1:30
Rabbit Anti-CERK Polyclonal Antibody – Cat# MBS2517893

Immunohistochemistry (IHC) of anti-CERK antibody

Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CERK Polyclonal Antibody at dilution 1:30
Rabbit Anti-CERK Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2517893

Other Notes

Small volumes of anti-CERK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CERK purchase

MBS2517893 is an antibody targeting CERK. Also known as CERK Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CERK. It may not necessarily be applicable to this product.

NCBI GI #
20336726
NCBI GeneID
64781
NCBI Accession #
NP_073603.2
UniProt Secondary Accession #
Q6NX59; Q9BYB3; Q9UGE5; A0JNT4; A8K611
UniProt Related Accession #
Q8TCT0
GenBank Nucleotide #
NM_022766.5
NCBI Official Full Name
ceramide kinase
NCBI Official Synonym Full Names
ceramide kinase
NCBI Official Symbol
CERK
NCBI Official Synonym Symbols
LK4; hCERK; dA59H18.2; dA59H18.3
UniProt Protein Name
Ceramide kinase
UniProt Synonym Protein Names
Acylsphingosine kinase; Lipid kinase 4; LK4
Protein Family
Ceramide kinase
UniProt Gene Name
CERK
UniProt Synonym Gene Names
KIAA1646; hCERK; LK4
UniProt Entry Name
CERK1_HUMAN
NCBI Protein Information
ceramide kinase; acylsphingosine kinase; lipid kinase 4; lipid kinase LK4

NCBI Summary for CERK

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]

UniProt Comments for CERK

CERK: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

Protein type: Kinase, lipid; EC 2.7.1.138; Lipid Metabolism - sphingolipid

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: mitochondrion; integral to membrane; plasma membrane

Molecular Function: ceramide kinase activity; magnesium ion binding; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity

Biological Process: sphingolipid metabolic process; protein kinase C activation; glycosphingolipid metabolic process; lipid phosphorylation; ceramide metabolic process; transmembrane transport
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Research Articles on CERK

1. our findings identify a functional role for Cerk in breast cancer recurrence and suggest the clinical utility of agents targeted against this prosurvival pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CERK antibody

 Reference Product  PubMed Publications
 SMPD1 antibody  >1 publications with CERK and SMPD1

Pathways associated with anti-CERK antibody

 Products by Pathway  Pathway Diagram
 Glycosphingolipid Metabolism Pathway antibodies  Glycosphingolipid Metabolism Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Orphan Transporters Pathway antibodies  Orphan Transporters Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-CERK antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >15 publications with CERK and Inflammation
 Disease Models, Animal Antibodies  >4 publications with CERK and Disease Models, Animal
 Necrosis Antibodies  >4 publications with CERK and Necrosis
 Insulin Resistance Antibodies  >2 publications with CERK and Insulin Resistance
 Breast Neoplasms Antibodies  >2 publications with CERK and Breast Neoplasms
 Kidney Diseases Antibodies  >2 publications with CERK and Kidney Diseases
 Liver Diseases Antibodies  >1 publications with CERK and Liver Diseases
 Adenocarcinoma Antibodies  >1 publications with CERK and Adenocarcinoma
 Glucose Intolerance Antibodies  >1 publications with CERK and Glucose Intolerance
 Hypertension Antibodies  >1 publications with CERK and Hypertension

Organs/Tissues associated with anti-CERK antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with CERK and Blood
 Bone Antibodies  >5 publications with CERK and Bone
 Brain Antibodies  >5 publications with CERK and Brain
 Eye Antibodies  >4 publications with CERK and Eye
 Vascular Antibodies  >4 publications with CERK and Vascular
 Bone Marrow Antibodies  >4 publications with CERK and Bone Marrow
 Liver Antibodies  >3 publications with CERK and Liver
 Kidney Antibodies  >3 publications with CERK and Kidney
 Spleen Antibodies  >3 publications with CERK and Spleen
 Skin Antibodies  >2 publications with CERK and Skin
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