Rabbit Anti-CHRM1 Polyclonal Antibody – Cat# MBS9132225

Western blot analysis of extracts of various cell lines, using CHRM1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.

CHRM1 Antibody – Rabbit Polyclonal

Name: CHRM1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9132225
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9132225

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition,… More details

$225 / 0.02 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CHRM1, Polyclonal Antibody

Full Product Name

CHRM1 Polyclonal Antibody

Product Gene Name

anti-CHRM1 antibody

Product Synonym Names

HM1; M1; M1R

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Purity/Purification

Affinity Purification

Preparation and Storage

Store at -20 degree C. Avoid freeze/thaw cycles.

Molecular Weight

51kDa

OMIM

Y00508 Genomic DNA

3D Structure

ModBase 3D Structure for P11229

Immunogen

A synthetic peptide of human CHRM1

Storage Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Product Categories/Family for anti-CHRM1 antibody

Primary antibody

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-CHRM1 antibody

Western Blot (WB)

Application Notes for anti-CHRM1 antibody

WB: 1:500 - 2000

Other Notes

Small volumes of anti-CHRM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHRM1 purchase

MBS9132225 is an antibody targeting CHRM1. Also known as CHRM1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CHRM1. It may not necessarily be applicable to this product.

NCBI GI #

113118

NCBI GeneID

1128

NCBI Accession #

P11229.2

UniProt Primary Accession #

P11229

UniProt Secondary Accession #

Q96RH1

UniProt Related Accession #

P11229

NCBI Official Full Name

Muscarinic acetylcholine receptor M1

NCBI Official Synonym Full Names

cholinergic receptor muscarinic 1

NCBI Official Symbol

CHRM1

NCBI Official Synonym Symbols

M1; HM1; M1R

UniProt Protein Name

Muscarinic acetylcholine receptor M1

Protein Family

Muscarinic acetylcholine receptor

UniProt Gene Name

CHRM1

NCBI Protein Information

muscarinic acetylcholine receptor M1

UniProt Comments for CHRM1

mAChR m1: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 11q12.3

Cellular Component: membrane; plasma membrane; synapse

Molecular Function: G-protein coupled acetylcholine receptor activity; phosphoinositide phospholipase C activity

Biological Process: acetylcholine receptor signaling, muscarinic pathway; cell proliferation; G-protein coupled receptor protein signaling pathway; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; muscarinic acetylcholine receptor, phospholipase C activating pathway; nervous system development; positive regulation of cell proliferation; positive regulation of ion transport; protein kinase C activation; protein modification process; regulation of vascular smooth muscle contraction; signal transduction; synaptic transmission, cholinergic

Research Articles on CHRM1

1. There were no significant associations between CHRM1 SNPs and autonomic nervous system activity in patients with schizophrenia on high-dose antipsychotics.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CHRM1 antibody

Products by Pathway	Pathway Diagram
Amine Ligand-binding Receptors Pathway antibodies	Amine Ligand-binding Receptors Pathway Diagram
Calcium Regulation In The Cardiac Cell Pathway antibodies	Calcium Regulation In The Cardiac Cell Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Cholinergic Synapse Pathway antibodies	Cholinergic Synapse Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram

Diseases associated with anti-CHRM1 antibody

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>17 publications with CHRM1 and Mental Disorders
Brain Diseases Antibodies	>7 publications with CHRM1 and Brain Diseases
Nervous System Diseases Antibodies	>6 publications with CHRM1 and Nervous System Diseases
Neurodegenerative Diseases Antibodies	>4 publications with CHRM1 and Neurodegenerative Diseases
Inflammation Antibodies	>3 publications with CHRM1 and Inflammation
Cognition Disorders Antibodies	>3 publications with CHRM1 and Cognition Disorders
Dementia Antibodies	>3 publications with CHRM1 and Dementia
Basal Ganglia Diseases Antibodies	>2 publications with CHRM1 and Basal Ganglia Diseases
Muscular Diseases Antibodies	>1 publications with CHRM1 and Muscular Diseases
Weight Loss Antibodies	>1 publications with CHRM1 and Weight Loss

Organs/Tissues associated with anti-CHRM1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>16 publications with CHRM1 and Brain
Kidney Antibodies	>4 publications with CHRM1 and Kidney
Eye Antibodies	>3 publications with CHRM1 and Eye
Lung Antibodies	>2 publications with CHRM1 and Lung
Prostate Antibodies	>2 publications with CHRM1 and Prostate