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CMKLR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9605005

Function: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CMKLR1, Polyclonal Antibody
Full Product Name
CMKLR1 Antibody
Product Gene Name
anti-CMKLR1 antibody
Product Synonym Names
CHEMERINR; Chemokine like receptor 1; Chemokine-like receptor 1; CHEMR23; CMKLR1; CML1_HUMAN; DEZ; G protein coupled receptor ChemR23; G protein coupled receptor DEZ; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; Orphan G protein coupled receptor; Orphan G protein coupled receptor Dez; Resolvin E1 receptor; RVER1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
CMKLR1 antibody detects endogenous levels of total CMKLR1
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
CMKLR1 peptide (MBS9623722) is used for blocking the activity of CMKLR1 antibody (MBS9605005)
Molecular Weight
Observed: 42 kD
Predicted: 43 kDa
3D Structure
ModBase 3D Structure for Q99788
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide
Subcellular Location
Cell Membrane
Tissue Specificity
Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CMKLR1 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-CMKLR1 antibody
WB: 1:500-1:1000
IF/ICC: 1:100-1:500

Immunofluorescence (IF) of anti-CMKLR1 antibody

MBS9605005 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Rabbit Anti-CMKLR1 Polyclonal Antibody – Cat# MBS9605005

Western Blot (WB) of anti-CMKLR1 antibody

Western blot analysis of extracts from HepG2 cells using CMKLR1 antibody.
Rabbit Anti-CMKLR1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9605005

Western Blot (WB) of anti-CMKLR1 antibody

Western blot analysis of extracts from mouse brain, using CMKLR1 Antibody.
Rabbit Anti-CMKLR1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9605005

Other Notes

Small volumes of anti-CMKLR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CMKLR1 purchase

MBS9605005 is an antibody targeting CMKLR1. Also known as CMKLR1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CMKLR1. It may not necessarily be applicable to this product.

NCBI GI #
215272317
NCBI GeneID
1240
NCBI Accession #
NP_001135815.1
UniProt Primary Accession #
Q99788
UniProt Secondary Accession #
O75748; Q3KP37; Q5U0H0; Q99789; A8K6Y5
UniProt Related Accession #
Q99788
GenBank Nucleotide #
NM_001142343.1
NCBI Official Full Name
chemokine-like receptor 1 isoform a
NCBI Official Synonym Full Names
chemerin chemokine-like receptor 1
NCBI Official Symbol
CMKLR1
NCBI Official Synonym Symbols
DEZ; RVER1; ChemR23; CHEMERINR
UniProt Protein Name
Chemokine-like receptor 1
UniProt Synonym Protein Names
G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ
UniProt Gene Name
CMKLR1
UniProt Synonym Gene Names
CHEMR23; DEZ
NCBI Protein Information
chemokine-like receptor 1

UniProt Comments for CMKLR1

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
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Research Articles on CMKLR1

1. CMKLR1 and GPR1 were widely expressed in vascular smooth muscle.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CMKLR1 antibody

 Products by Pathway  Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-CMKLR1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >42 publications with CMKLR1 and Inflammation
 Necrosis Antibodies  >10 publications with CMKLR1 and Necrosis
 Lung Diseases Antibodies  >7 publications with CMKLR1 and Lung Diseases
 Disease Models, Animal Antibodies  >6 publications with CMKLR1 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >5 publications with CMKLR1 and Cardiovascular Diseases
 Liver Diseases Antibodies  >4 publications with CMKLR1 and Liver Diseases
 Pain Antibodies  >4 publications with CMKLR1 and Pain
 Pneumonia Antibodies  >3 publications with CMKLR1 and Pneumonia
 Fatty Liver Antibodies  >2 publications with CMKLR1 and Fatty Liver
 Lung Neoplasms Antibodies  >2 publications with CMKLR1 and Lung Neoplasms

Organs/Tissues associated with anti-CMKLR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >43 publications with CMKLR1 and Blood
 Adipose Tissue Antibodies  >16 publications with CMKLR1 and Adipose Tissue
 Lung Antibodies  >11 publications with CMKLR1 and Lung
 Bone Antibodies  >11 publications with CMKLR1 and Bone
 Connective Tissue Antibodies  >11 publications with CMKLR1 and Connective Tissue
 Heart Antibodies  >6 publications with CMKLR1 and Heart
 Spleen Antibodies  >3 publications with CMKLR1 and Spleen
 Brain Antibodies  >3 publications with CMKLR1 and Brain
 Kidney Antibodies  >2 publications with CMKLR1 and Kidney
 Uterus Antibodies  >2 publications with CMKLR1 and Uterus
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