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CNGA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2524834

The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the… More details

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Product Overview

Online Datasheet in PDF
Product Name
CNGA1, Polyclonal Antibody
Full Product Name
CNGA1 Polyclonal Antibody
Product Gene Name
anti-CNGA1 antibody
Product Synonym Names
CNCG, CNG1, RP49, CNCG1, CNG-1, RCNC1, RCNCa, RCNCalpha
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
86,900 Da
OMIM
123825
Immunogen
Synthetic peptide of human CNGA1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CNGA1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-CNGA1 antibody
IHC: 1:25-1:100

Immunohistochemistry (IHC) of anti-CNGA1 antibody

Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CNGA1 Polyclonal Antibody at dilution 1:40
Rabbit Anti-CNGA1 Polyclonal Antibody – Cat# MBS2524834

Other Notes

Small volumes of anti-CNGA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CNGA1 purchase

MBS2524834 is an antibody targeting CNGA1. Also known as CNGA1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CNGA1. It may not necessarily be applicable to this product.

NCBI GI #
71143141
NCBI GeneID
1259
NCBI Accession #
NP_000078.2
UniProt Secondary Accession #
Q16279; Q16485; Q4W5E3; A8K7K6; J3KPZ2
UniProt Related Accession #
P29973
GenBank Nucleotide #
NM_000087.3
NCBI Official Full Name
cGMP-gated cation channel alpha-1 isoform 2
NCBI Official Synonym Full Names
cyclic nucleotide gated channel alpha 1
NCBI Official Symbol
CNGA1
NCBI Official Synonym Symbols
CNCG; CNG1; RP49; CNCG1; CNG-1; RCNC1; RCNCa; RCNCalpha
UniProt Protein Name
cGMP-gated cation channel alpha-1
UniProt Synonym Protein Names
Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha
Protein Family
cGMP-gated cation channel
UniProt Gene Name
CNGA1
UniProt Synonym Gene Names
CNCG; CNCG1; CNG channel alpha-1; CNG-1; CNG1
UniProt Entry Name
CNGA1_HUMAN
NCBI Protein Information
cGMP-gated cation channel alpha-1; CNG channel alpha-1; cyclic nucleotide-gated cation channel 1; cyclic nucleotide-gated channel alpha-1; cyclic nucleotide-gated channel, photoreceptor; interleukin-1 homologue; rod photoreceptor cGMP-gated channel subunit alpha

UniProt Comments for CNGA1

CNGA1: a cyclic nucleotide-gated cation channel of rod cells in the retina. Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. Activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. CNG ion channels exist in the retinal, olfactory and cochlear sensory neurons.

Protein type: Membrane protein, integral; Channel, cation; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: voltage-gated potassium channel activity; protein binding; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; cGMP binding

Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of membrane potential; regulation of rhodopsin mediated signaling; visual perception; transport

Disease: Retinitis Pigmentosa 49; Retinitis Pigmentosa
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Research Articles on CNGA1

1. Insulin receptor (IR), an integral membrane protein, directly phosphorylates the CNGA1 subunit of CNG channels that in turn affects the function of these channels negatively. CNGA1 is a direct substrate of IR.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CNGA1 antibody

 Reference Product  PubMed Publications
 CNGB1 antibody  >22 publications with CNGA1 and CNGB1
 PDE6B antibody  >5 publications with CNGA1 and PDE6B
 PDE6A antibody  >2 publications with CNGA1 and PDE6A

Pathways associated with anti-CNGA1 antibody

 Products by Pathway  Pathway Diagram
 Activation Of The Phototransduction Cascade Pathway antibodies  Activation Of The Phototransduction Cascade Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway antibodies  Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway Diagram
 Phototransduction Pathway antibodies  Phototransduction Pathway Diagram
 Phototransduction Pathway antibodies  Phototransduction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Phototransduction Cascade Pathway antibodies  The Phototransduction Cascade Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram
 Visual Signal Transduction: Rods Pathway antibodies  Visual Signal Transduction: Rods Pathway Diagram

Diseases associated with anti-CNGA1 antibody

 Disease Name  Pubmed Publications
 Retinitis Pigmentosa Antibodies  >14 publications with CNGA1 and Retinitis Pigmentosa
 Disease Models, Animal Antibodies  >3 publications with CNGA1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >3 publications with CNGA1 and Nervous System Diseases
 Edema Antibodies  >1 publications with CNGA1 and Edema
 Immune System Diseases Antibodies  >1 publications with CNGA1 and Immune System Diseases
 Immunologic Deficiency Syndromes Antibodies  >1 publications with CNGA1 and Immunologic Deficiency Syndromes

Organs/Tissues associated with anti-CNGA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >30 publications with CNGA1 and Eye
 Kidney Antibodies  >4 publications with CNGA1 and Kidney
 Muscle Antibodies  >3 publications with CNGA1 and Muscle
 Brain Antibodies  >3 publications with CNGA1 and Brain
 Mouth Antibodies  >1 publications with CNGA1 and Mouth
 Heart Antibodies  >1 publications with CNGA1 and Heart
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