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COX17 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9600468

Description: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by… More details

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Product Overview

Online Datasheet in PDF
Product Name
COX17, Polyclonal Antibody
Full Product Name
COX17 Antibody
Product Gene Name
anti-COX17 antibody
Product Synonym Names
COX 17; COX17; COX17 cytochrome c oxidase assembly homolog (S. cerevisiae); COX17 cytochrome c oxidase assembly homolog; COX17 homolog cytochrome c oxidase assembly protein; COX17_HUMAN; cytochrome c oxidase assembly protein cox17 homolog; Cytochrome c oxidase copper chaperone; Human homolog of yeast mitochondrial copper recruitment; MGC104397; MGC117386; OTTHUMP00000215284; OTTHUMP00000215285
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
COX17 antibody detects endogenous levels of COX17
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
COX17 peptide (MBS9615021) is used for blocking the activity of COX17 antibody (MBS9600468)
Molecular Weight
Observed: 7 kDa
Predicted: 7 kDa
3D Structure
ModBase 3D Structure for Q14061
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human COX17
Subcellular Location
Mitochondrion Intermembrane Space.
Tissue Specificity
Ubiquitous.
Predicted Cross Reactivity
Pig, Bovine, Dog, Xenopus
Similarity
Pig (100%), Bovine (91%), Dog (82%), Xenopus (100%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-COX17 antibody
Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-COX17 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IF/ICC: 1:100-1:500

Western Blot (WB) of anti-COX17 antibody

Western blot analysis on HeLa cell lysate using COX17 Antibody, The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-COX17 Polyclonal Antibody – Cat# MBS9600468

Western Blot (WB) of anti-COX17 antibody

Western blot analysis of extracts from 293, using COX17 Antibody.
Rabbit Anti-COX17 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9600468

Immunohistochemistry (IHC) of anti-COX17 antibody

MBS9600468 at 1/100 staining human skeletal muscle tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-COX17 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9600468

Immunofluorescence (IF) of anti-COX17 antibody

MBS9600468 staining HeLa by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Rabbit Anti-COX17 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9600468

Other Notes

Small volumes of anti-COX17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COX17 purchase

MBS9600468 is an antibody targeting COX17. Also known as COX17 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for COX17. It may not necessarily be applicable to this product.

NCBI GI #
5031645
NCBI GeneID
10063
NCBI Accession #
NP_005685.1
UniProt Primary Accession #
Q14061
UniProt Secondary Accession #
Q3MHD6; B2R5D2; D3DN84
UniProt Related Accession #
Q14061
GenBank Nucleotide #
NM_005694.1
NCBI Official Full Name
cytochrome c oxidase copper chaperone
NCBI Official Synonym Full Names
cytochrome c oxidase copper chaperone COX17
NCBI Official Symbol
COX17
UniProt Protein Name
Cytochrome c oxidase copper chaperone
Protein Family
Cytochrome c oxidase copper chaperone
UniProt Gene Name
COX17
NCBI Protein Information
cytochrome c oxidase copper chaperone

NCBI Summary for COX17

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]
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UniProt Comments for COX17

Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
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Research Articles on COX17

1. These results collectively indicate that Cox17 might not participate in the action of these anticancer organoruthenium complexes, and further verify the distinct anticancer mechanism of the organoruthenium(II) complexes from cisplatin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-COX17 antibody

 Products by Pathway  Pathway Diagram
 Cytochrome C Oxidase Pathway antibodies  Cytochrome C Oxidase Pathway Diagram
 Cytochrome C Oxidase Pathway antibodies  Cytochrome C Oxidase Pathway Diagram
 Electron Transport Chain Pathway antibodies  Electron Transport Chain Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mitochondrial Protein Import Pathway antibodies  Mitochondrial Protein Import Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram

Diseases associated with anti-COX17 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with COX17 and Nervous System Diseases
 Hypertrophy Antibodies  >2 publications with COX17 and Hypertrophy
 Drug Toxicity Antibodies  >2 publications with COX17 and Drug Toxicity
 Liver Diseases Antibodies  >2 publications with COX17 and Liver Diseases
 Neoplasms Antibodies  >1 publications with COX17 and Neoplasms

Organs/Tissues associated with anti-COX17 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >7 publications with COX17 and Liver
 Heart Antibodies  >5 publications with COX17 and Heart
 Brain Antibodies  >4 publications with COX17 and Brain
 Intestine Antibodies  >3 publications with COX17 and Intestine
 Muscle Antibodies  >3 publications with COX17 and Muscle
 Embryonic Tissue Antibodies  >2 publications with COX17 and Embryonic Tissue
 Blood Antibodies  >1 publications with COX17 and Blood
 Kidney Antibodies  >1 publications with COX17 and Kidney
 Eye Antibodies  >1 publications with COX17 and Eye
 Lung Antibodies  >1 publications with COX17 and Lung
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