BC001271
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
CYR61
NCBI Official Synonym Full Names
cysteine-rich, angiogenic inducer, 61
NCBI Protein Information
protein CYR61; CCN family member 1; IBP-10; IGF-binding protein 10; IGFBP-10; cysteine-rich heparin-binding protein 61; cysteine-rich, anigogenic inducer, 61; insulin-like growth factor-binding protein 10
UniProt Protein Name
CYR61 protein
UniProt Synonym Protein Names
CYR61 protein
UniProt Entry Name
Q6FI18_HUMAN
NCBI Summary for CYR61
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
UniProt Comments for CYR61
CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1p22.3
Cellular Component: extracellular matrix; proteinaceous extracellular matrix
Molecular Function: heparin binding; integrin binding; insulin-like growth factor binding; extracellular matrix binding
Biological Process: anatomical structure morphogenesis; extracellular matrix organization and biogenesis; positive regulation of caspase activity; chemotaxis; intussusceptive angiogenesis; osteoblast differentiation; positive regulation of osteoblast differentiation; cell proliferation; cell-cell signaling; positive regulation of protein kinase activity; positive regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell growth; positive regulation of protein amino acid phosphorylation; cell adhesion; positive regulation of BMP signaling pathway; negative regulation of apoptosis; positive regulation of cell migration
Research Articles on CYR61
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Pathways associated with anti-CYR61 antibody
Diseases associated with anti-CYR61 antibody
Organs/Tissues associated with anti-CYR61 antibody
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