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DCP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS9128376
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The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its… More details

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Product Overview

Online Datasheet in PDF
Product Name
DCP2, Polyclonal Antibody
Full Product Name
DCP2 Polyclonal Antibody
Product Gene Name
anti-DCP2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
48kDa
OMIM
609844
3D Structure
ModBase 3D Structure for Q8IU60
Immunogen
Recombinant protein of human DCP2
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-DCP2 antibody
Western Blot (WB)
Application Notes for anti-DCP2 antibody
WB 1:500 - 1:2000

Western Blot (WB) of anti-DCP2 antibody

Western blot analysis of extracts of various cell lines, using DCP2 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Rabbit Anti-DCP2 Polyclonal Antibody – Cat# MBS9128376

Immunohistochemistry (IHC) of anti-DCP2 antibody

Immunohistochemistry of paraffin-embedded mouse lung using DCP2 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-DCP2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9128376

Immunohistochemistry (IHC) of anti-DCP2 antibody

Immunohistochemistry of paraffin-embedded rat kidney using DCP2 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-DCP2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9128376

Immunohistochemistry (IHC) of anti-DCP2 antibody

Immunohistochemistry of paraffin-embedded human liver injury using DCP2 antibody at dilution of 1:100 (40x lens).
Rabbit Anti-DCP2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9128376

Immunofluorescence (IF) of anti-DCP2 antibody

Immunofluorescence analysis of U2OS cells using DCP2 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Rabbit Anti-DCP2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9128376

Other Notes

Small volumes of anti-DCP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DCP2 purchase

MBS9128376 is an antibody targeting DCP2. Also known as DCP2 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DCP2. It may not necessarily be applicable to this product.

NCBI GI #
334688848
NCBI GeneID
167227
NCBI Accession #
NP_001229306.1
UniProt Primary Accession #
Q8IU60
UniProt Secondary Accession #
Q6P2D4; Q7Z5W5; Q8NBG5; C9J778
UniProt Related Accession #
Q8IU60
GenBank Nucleotide #
NM_001242377.1
NCBI Official Full Name
m7GpppN-mRNA hydrolase isoform 2
NCBI Official Synonym Full Names
decapping mRNA 2
NCBI Official Symbol
DCP2
NCBI Official Synonym Symbols
NUDT20
UniProt Protein Name
m7GpppN-mRNA hydrolase
UniProt Synonym Protein Names
Nucleoside diphosphate-linked moiety X motif 20; Nudix motif 20; mRNA-decapping enzyme 2; hDpc
Protein Family
m7GpppN-mRNA hydrolase
UniProt Gene Name
DCP2
UniProt Synonym Gene Names
NUDT20; Nudix motif 20; hDpc
UniProt Entry Name
DCP2_HUMAN
NCBI Protein Information
m7GpppN-mRNA hydrolase

UniProt Comments for DCP2

DCP2: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking a RNA moiety. Belongs to the Nudix hydrolase family. DCP2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing; Hydrolase; EC 3.6.1.62

Chromosomal Location of Human Ortholog: 5q22.2

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cell junction; cytosol

Molecular Function: m7G(5')pppN diphosphatase activity; protein binding; exoribonuclease activity, producing 5'-phosphomonoesters; RNA binding; manganese ion binding

Biological Process: mRNA catabolic process, nonsense-mediated decay; mRNA catabolic process; gene expression; mRNA catabolic process, deadenylation-dependent decay
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Research Articles on DCP2

1. Human Dcp2 levels and activity are controlled by a competition between decapping complex assembly and Dcp2 degradation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DCP2 antibody

 Reference Product  PubMed Publications
 XRN1 antibody  >25 publications with DCP2 and XRN1
 EDC3 antibody  >24 publications with DCP2 and EDC3
 LSM1 antibody  >21 publications with DCP2 and LSM1
 EDC4 antibody  >15 publications with DCP2 and EDC4
 DDX6 antibody  >11 publications with DCP2 and DDX6
 UPF1 antibody  >7 publications with DCP2 and UPF1
 PATL1 antibody  >5 publications with DCP2 and PATL1
 LSM4 antibody  >3 publications with DCP2 and LSM4
 ZFP36 antibody  >2 publications with DCP2 and ZFP36
 DCP1B antibody  >1 publications with DCP2 and DCP1B

Pathways associated with anti-DCP2 antibody

 Products by Pathway  Pathway Diagram
 ATF4 Activates Genes Pathway antibodies  ATF4 Activates Genes Pathway Diagram
 Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway antibodies  Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Decapping Complex Pathway antibodies  Decapping Complex Pathway Diagram
 Decapping Complex Pathway antibodies  Decapping Complex Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 KSRP Destabilizes MRNA Pathway antibodies  KSRP Destabilizes MRNA Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 PERK Regulates Gene Expression Pathway antibodies  PERK Regulates Gene Expression Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram

Diseases associated with anti-DCP2 antibody

 Disease Name  Pubmed Publications
 Fever Antibodies  >2 publications with DCP2 and Fever
 Nervous System Diseases Antibodies  >2 publications with DCP2 and Nervous System Diseases
 Inflammation Antibodies  >2 publications with DCP2 and Inflammation
 Liver Diseases Antibodies  >1 publications with DCP2 and Liver Diseases
 Necrosis Antibodies  >1 publications with DCP2 and Necrosis

Organs/Tissues associated with anti-DCP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with DCP2 and Blood
 Heart Antibodies  >1 publications with DCP2 and Heart
 Liver Antibodies  >1 publications with DCP2 and Liver
 Bone Marrow Antibodies  >1 publications with DCP2 and Bone Marrow
 Testis Antibodies  >1 publications with DCP2 and Testis
 Embryonic Tissue Antibodies  >1 publications with DCP2 and Embryonic Tissue
 Brain Antibodies  >1 publications with DCP2 and Brain
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