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DOK1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624915

DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with… More details

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Product Overview

Online Datasheet in PDF
Product Name
Dok1, Polyclonal Antibody
Full Product Name
Dok1, phosphorylated (Tyr398) (Docking Protein 1, Downstream Of Tyrosine Kinase 1, MGC117395, MGC138860, p62(dok), p62dok, P62DOK, pp62)
Product Gene Name
anti-DOK1 antibody
Product Synonym Names
Anti -Dok1, phosphorylated (Tyr398) (Docking Protein 1, Downstream Of Tyrosine Kinase 1, MGC117395, MGC138860, p62(dok), p62dok, P62DOK, pp62)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Dok1 when phosphorylated at tyrosine 398. Species Cross-Reactivity: mouse, rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
52,420 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (74781860..74784663). Location: 2p13
3D Structure
ModBase 3D Structure for Q53GP8
Immunogen
Synthetic phosphopeptide corresponding to human Dok1 around the phosphorylation site of tyrosine 398 (E-G-YP-E-L).

Product Categories/Family for anti-DOK1 antibody

Antibodies; Abs to Signal Transduction
Applications Tested/Suitable for anti-DOK1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DOK1 antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot:1:500-1:1,000
Immunohistochemistry:1:50-1:100

Other Notes

Small volumes of anti-DOK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DOK1 purchase

MBS624915 is an antibody targeting DOK1. Also known as Dok1, phosphorylated (Tyr398) (Docking Protein 1, Downstream Of Tyrosine Kinase 1, MGC117395, MGC138860, p62(dok), p62dok, P62DOK, pp62). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DOK1. It may not necessarily be applicable to this product.

NCBI GI #
4503357
NCBI GeneID
1796
NCBI Accession #
NP_001372.1
UniProt Primary Accession #
Q53GP8
UniProt Related Accession #
Q14CB2; Q2TA81; Q53GP8; Q99704
GenBank Nucleotide #
NM_001381.3
NCBI Official Full Name
docking protein 1 isoform 1
NCBI Official Synonym Full Names
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
NCBI Official Symbol
DOK1
NCBI Official Synonym Symbols
P62DOK; MGC117395; MGC138860
UniProt Protein Name
Docking protein 1 variant
Protein Family
Docking protein
UniProt Entry Name
Q53GP8_HUMAN
NCBI Protein Information
docking protein 1; pp62; p62(dok); OTTHUMP00000160414; OTTHUMP00000202719; Downstream of tyrosine kinase 1; docking protein 1 (downstream of tyrosine kinase 1)

NCBI Summary for DOK1

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for DOK1

DOK1: a docking protein that interacts with receptor tyrosine kinases. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; receptor signaling protein activity; insulin receptor binding

Biological Process: cell surface receptor linked signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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Research Articles on DOK1

1. Dok1 negatively regulates Dok2-mediated CD200R signaling through the recruitment of CrkL.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DOK1 antibody

 Reference Product  PubMed Publications
 SRC antibody  >56 publications with DOK1 and SRC
 CSK antibody  >8 publications with DOK1 and CSK
 RET antibody  >7 publications with DOK1 and RET
 CRKL antibody  >6 publications with DOK1 and CRKL
 LCK antibody  >5 publications with DOK1 and LCK
 TEC antibody  >5 publications with DOK1 and TEC
 FYN antibody  >4 publications with DOK1 and FYN
 LYN antibody  >3 publications with DOK1 and LYN
 KIT antibody  >3 publications with DOK1 and KIT
 SHC1 antibody  >3 publications with DOK1 and SHC1

Pathways associated with anti-DOK1 antibody

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 IRS Activation Pathway antibodies  IRS Activation Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Pathway antibodies  IRS-related Events Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram
 Insulin Receptor Signalling Cascade Pathway antibodies  Insulin Receptor Signalling Cascade Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram

Diseases associated with anti-DOK1 antibody

 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >9 publications with DOK1 and Cell Transformation, Neoplastic
 Carcinoma Antibodies  >5 publications with DOK1 and Carcinoma
 Adenocarcinoma Antibodies  >3 publications with DOK1 and Adenocarcinoma
 Thyroid Diseases Antibodies  >2 publications with DOK1 and Thyroid Diseases
 Thyroid Neoplasms Antibodies  >2 publications with DOK1 and Thyroid Neoplasms
 Congenital Abnormalities Antibodies  >2 publications with DOK1 and Congenital Abnormalities
 Melanoma, Experimental Antibodies  >1 publications with DOK1 and Melanoma, Experimental
 Liver Diseases Antibodies  >1 publications with DOK1 and Liver Diseases
 Body Weight Changes Antibodies  >1 publications with DOK1 and Body Weight Changes
 Diabetes Mellitus, Type 2 Antibodies  >1 publications with DOK1 and Diabetes Mellitus, Type 2

Organs/Tissues associated with anti-DOK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with DOK1 and Blood
 Bone Antibodies  >14 publications with DOK1 and Bone
 Bone Marrow Antibodies  >14 publications with DOK1 and Bone Marrow
 Lung Antibodies  >6 publications with DOK1 and Lung
 Muscle Antibodies  >6 publications with DOK1 and Muscle
 Embryonic Tissue Antibodies  >4 publications with DOK1 and Embryonic Tissue
 Adipose Tissue Antibodies  >3 publications with DOK1 and Adipose Tissue
 Connective Tissue Antibodies  >3 publications with DOK1 and Connective Tissue
 Spleen Antibodies  >3 publications with DOK1 and Spleen
 Heart Antibodies  >3 publications with DOK1 and Heart
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