DPYD Antibody – Rabbit Polyclonal

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

DPYD: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. Homodimer. Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells. Belongs to the dihydropyrimidine dehydrogenase family.

Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 1.3.1.2; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes

Chromosomal Location of Human Ortholog: 1p21.3

Cellular Component: cytoplasm; cytosol

Molecular Function: dihydropyrimidine dehydrogenase (NADP+) activity; FAD binding; NADP binding; protein binding; protein homodimerization activity

Biological Process: purine base catabolic process; pyrimidine base catabolic process; pyrimidine nucleoside catabolic process; thymidine catabolic process; thymine catabolic process; uracil catabolic process

Disease: Dihydropyrimidine Dehydrogenase Deficiency