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DRD4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9507900

MBS9507900 is an antibody targeting DRD4. Also known as DRD4 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$300 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DRD4, Polyclonal Antibody
Full Product Name
DRD4 Antibody
Product Gene Name
anti-DRD4 antibody
Product Synonym Names
D(4) dopamine receptor; Dopamine D4 receptor; D(2C) dopamine receptor; DRD4
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Concentration
1 mg/ml (lot specific)
Specificity
DRD4 Antibody detects endogenous levels of total DRD4 protein.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Molecular Weight
48 kDa
OMIM
L12398 mRNA
3D Structure
ModBase 3D Structure for P21917
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human DRD4.
Immunogen Range
355-404
Applications Tested/Suitable for anti-DRD4 antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-DRD4 antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:40000

Immunofluorescence (IF) of anti-DRD4 antibody

Immunofluorescence analysis of MCF7 cells, using DRD4 Antibody. The picture on the right is blocked with the synthesized peptide.
Rabbit Anti-DRD4 Polyclonal Antibody – Cat# MBS9507900

Western Blot (WB) of anti-DRD4 antibody

Western blot analysis of lysates from MCF-7 and HUVEC cells, using DRD4 Antibody. The lane on the right is blocked with the synthesized peptide.
Rabbit Anti-DRD4 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9507900

Other Notes

Small volumes of anti-DRD4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DRD4. It may not necessarily be applicable to this product.

NCBI GI #
32483397
NCBI GeneID
1815
NCBI Accession #
NP_000788.2
UniProt Primary Accession #
P21917
UniProt Secondary Accession #
Q7Z7Q5; Q8NGM5; B0M0J7
UniProt Related Accession #
P21917
GenBank Nucleotide #
NM_000797.3
NCBI Official Full Name
D(4) dopamine receptor
NCBI Official Synonym Full Names
dopamine receptor D4
NCBI Official Symbol
DRD4
NCBI Official Synonym Symbols
D4DR
UniProt Protein Name
D(4) dopamine receptor
UniProt Synonym Protein Names
D(2C) dopamine receptor; Dopamine D4 receptor
Protein Family
D(4) dopamine receptor
UniProt Gene Name
DRD4
NCBI Protein Information
D(4) dopamine receptor

NCBI Summary for DRD4

This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
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UniProt Comments for DRD4

Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells ().
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Research Articles on DRD4

1. The neurotransmitter dopamine is linked to brain areas associated with reward, motivation, and attention, and common dopaminergic variants, DRD$ and DRD2 have been associated with attention difficulties.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DRD4 antibody

 Reference Product  PubMed Publications
 SRC antibody  >2 publications with DRD4 and SRC
 GRB2 antibody  >1 publications with DRD4 and GRB2

Pathways associated with anti-DRD4 antibody

 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Dopamine Receptors Pathway antibodies  Dopamine Receptors Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram

Diseases associated with anti-DRD4 antibody

 Disease Name  Pubmed Publications
 Attention Deficit Disorder with Hyperactivity Antibodies  >287 publications with DRD4 and Attention Deficit Disorder with Hyperactivity
 Attention Deficit and Disruptive Behavior Disorders Antibodies  >241 publications with DRD4 and Attention Deficit and Disruptive Behavior Disorders
 Schizophrenia Antibodies  >192 publications with DRD4 and Schizophrenia
 Substance-Related Disorders Antibodies  >119 publications with DRD4 and Substance-Related Disorders
 Nervous System Diseases Antibodies  >102 publications with DRD4 and Nervous System Diseases
 Movement Disorders Antibodies  >51 publications with DRD4 and Movement Disorders
 NOVELTY SEEKING PERSONALITY TRAIT Antibodies  >47 publications with DRD4 and NOVELTY SEEKING PERSONALITY TRAIT
 Anxiety Disorders Antibodies  >38 publications with DRD4 and Anxiety Disorders
 Basal Ganglia Diseases Antibodies  >36 publications with DRD4 and Basal Ganglia Diseases
 Cognition Disorders Antibodies  >25 publications with DRD4 and Cognition Disorders

Organs/Tissues associated with anti-DRD4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >331 publications with DRD4 and Brain
 Ovary Antibodies  >21 publications with DRD4 and Ovary
 Eye Antibodies  >18 publications with DRD4 and Eye
 Kidney Antibodies  >16 publications with DRD4 and Kidney
 Bone Antibodies  >1 publications with DRD4 and Bone
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