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DST Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9607408

Description: This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants… More details

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Product Overview

Online Datasheet in PDF
Product Name
DST, Polyclonal Antibody
Full Product Name
DST Antibody
Product Gene Name
anti-DST antibody
Product Synonym Names
230 kDa bullous pemphigoid antigen; 230/240 kDa bullous pemphigoid antigen; BP230; BP240; BPA; BPAG1; Bullous pemphigoid antigen 1; Bullous pemphigoid antigen; DMH; DST; DT; Dystonia musculorum protein; Hemidesmosomal plaque protein; KIAA0728
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
~1mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
DST peptide (MBS9626124) is used for blocking the activity of DST antibody (MBS9607408)
Molecular Weight
861 kDa, 100 kDa
3D Structure
ModBase 3D Structure for Q03001
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human DST, corresponding to a region within the C-terminal amino acids
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-DST antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-DST antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IF/ICC: 1:100-1:500
The optimal dilutions should be determined by the end user.
IMPORTANT: For western blot, incubate membrane with diluted primary Ab in 5% w/v milk , 1X TBS, 0.1% Tween20 at 4 degree C with gentle shaking, overnight.

Western Blot (WB) of anti-DST antibody

Western blot analysis of extracts from various samples, using DST Ab.
Lane 1: 3T3, treated with blocking peptide;
Lane 2: 3T3;
Lane 3: Colo205.
Observed bands: 100 kDa.
Rabbit Anti-DST Polyclonal Antibody – Cat# MBS9607408

Immunohistochemistry (IHC) of anti-DST antibody

MBS9607408 at 1/100 staining Human lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-DST Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9607408

Other Notes

Small volumes of anti-DST antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DST purchase

MBS9607408 is an antibody targeting DST. Also known as DST Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DST. It may not necessarily be applicable to this product.

NCBI GI #
221316618
NCBI GeneID
667
NCBI Accession #
NP_001138241.1
UniProt Primary Accession #
Q03001
UniProt Secondary Accession #
O94833; Q12825; Q13266; Q13267; Q13775; Q5TBT0; Q5TBT2; Q5TF23; Q5TF24; B7Z3H1; E7ERU0
UniProt Related Accession #
Q03001
GenBank Nucleotide #
NM_001144769.2
NCBI Official Full Name
dystonin isoform 2
NCBI Official Synonym Full Names
dystonin
NCBI Official Symbol
DST
NCBI Official Synonym Symbols
DT; BPA; DMH; BP240; BPAG1; EBSB2; HSAN6; MACF2; CATX15; CATX-15; D6S1101
UniProt Protein Name
Dystonin
UniProt Synonym Protein Names
230 kDa bullous pemphigoid antigen; 230/240 kDa bullous pemphigoid antigen; Bullous pemphigoid antigen 1; BPA; Bullous pemphigoid antigen; Dystonia musculorum protein; Hemidesmosomal plaque protein
Protein Family
Dystonin
UniProt Gene Name
DST
UniProt Synonym Gene Names
BP230; BP240; BPAG1; DMH; DT; KIAA0728; BPA; Bullous pemphigoid antigen
NCBI Protein Information
dystonin

NCBI Summary for DST

This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]
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UniProt Comments for DST

Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 ().
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Research Articles on DST

1. A report on 2 novel heterozygous mutations in the dystonin (DST) gene from a family with hereditary sensory and autonomic neuropathy type VI. Induced-pluripotent stem cells findings suggest that the dystonin defect might alter proper development of the peripheral nerves

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DST antibody

 Reference Product  PubMed Publications
 ITGB4 antibody  >27 publications with DST and ITGB4
 COL17A1 antibody  >17 publications with DST and COL17A1
 KRT14 antibody  >4 publications with DST and KRT14
 ERBB2IP antibody  >1 publications with DST and ERBB2IP
 SPAG5 antibody  >1 publications with DST and SPAG5

Pathways associated with anti-DST antibody

 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Type I Hemidesmosome Assembly Pathway antibodies  Type I Hemidesmosome Assembly Pathway Diagram

Diseases associated with anti-DST antibody

 Disease Name  Pubmed Publications
 Depressive Disorder Antibodies  >812 publications with DST and Depressive Disorder
 Nervous System Diseases Antibodies  >363 publications with DST and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >216 publications with DST and Cardiovascular Diseases
 Lung Diseases Antibodies  >179 publications with DST and Lung Diseases
 Weight Loss Antibodies  >91 publications with DST and Weight Loss
 Inflammation Antibodies  >77 publications with DST and Inflammation
 Disease Models, Animal Antibodies  >61 publications with DST and Disease Models, Animal
 Liver Diseases Antibodies  >61 publications with DST and Liver Diseases
 Cognition Disorders Antibodies  >47 publications with DST and Cognition Disorders
 Adenocarcinoma Antibodies  >36 publications with DST and Adenocarcinoma

Organs/Tissues associated with anti-DST antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2573 publications with DST and Blood
 Nerve Antibodies  >540 publications with DST and Nerve
 Skin Antibodies  >456 publications with DST and Skin
 Brain Antibodies  >450 publications with DST and Brain
 Lung Antibodies  >208 publications with DST and Lung
 Heart Antibodies  >190 publications with DST and Heart
 Pancreas Antibodies  >179 publications with DST and Pancreas
 Kidney Antibodies  >162 publications with DST and Kidney
 Liver Antibodies  >118 publications with DST and Liver
 Vascular Antibodies  >111 publications with DST and Vascular
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