NP_001955.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
57,507 Da
NCBI Official Full Name
early growth response protein 1
NCBI Official Synonym Full Names
early growth response 1
NCBI Official Synonym Symbols
TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268 [Similar Products]
NCBI Protein Information
early growth response protein 1; EGR-1; nerve growth factor-induced protein A; transcription factor ETR103; transcription factor Zif268; zinc finger protein 225; zinc finger protein Krox-24
UniProt Protein Name
Early growth response protein 1
UniProt Synonym Protein Names
AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24
UniProt Synonym Gene Names
UniProt Entry Name
EGR1_HUMAN
NCBI Summary for EGR1
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]
UniProt Comments for EGR1
EGR1: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. By growth factors. Belongs to the EGR C2H2-type zinc-finger protein family.
Protein type: DNA-binding; C2H2-type zinc finger protein; Transcription factor
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: histone acetyltransferase binding; protein binding; DNA binding; sequence-specific DNA binding; metal ion binding; double-stranded DNA binding; transcription factor activity; transcription factor binding
Biological Process: response to nutrient levels; transcription from RNA polymerase II promoter; circadian rhythm; regulation of long-term neuronal synaptic plasticity; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; response to amphetamine; negative regulation of transcription from RNA polymerase II promoter; response to cocaine; BMP signaling pathway; learning and/or memory; response to ethanol; cellular response to insulin stimulus; positive regulation of neuron apoptosis; response to glucose stimulus; oligodendrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; response to electrical stimulus; T cell differentiation; regulation of protein sumoylation; negative regulation of apoptosis
Research Articles on EGR1
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Products associated with anti-EGR1 antibody
Pathways associated with anti-EGR1 antibody
Diseases associated with anti-EGR1 antibody
Organs/Tissues associated with anti-EGR1 antibody
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