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EIF6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS4510370

MBS4510370 is an antibody targeting EIF6. Also known as Rabbit anti-EIF6 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$265 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EIF6, Polyclonal Antibody
Full Product Name
Rabbit anti-EIF6 Antibody
Product Gene Name
anti-EIF6 antibody
Product Synonym Names
EIF3A; ITGB4BP; Eukaryotic translation initiation factor 6; eIF-6; B(2)GCN homolog; B4 integrin interactor; CAB; p27(BBP)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Concentration
1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid repeated freeze/thaw cycles.
Molecular Weight
245
OMIM
602912
3D Structure
ModBase 3D Structure for P56537
Immunogen
Recombinant full length protein of human EIF6

Product Categories/Family for anti-EIF6 antibody

Primary antibodies
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-EIF6 antibody
Western Blot (WB), Immunofluorescence (IF), Immunochemistry (IC)
Application Notes for anti-EIF6 antibody
WB: 1:500-1:2000
IF:IC: 1:50-1:200

Western Blot (WB) of anti-EIF6 antibody

Western blot analysis of EIF6 expression in Hela (A), HepG2 (B), K562 (C) whole cell lysates.
Rabbit Anti-EIF6 Polyclonal Antibody – Cat# MBS4510370

Immunofluorescence (IF) of anti-EIF6 antibody

Immunofluorescent analysis of EIF6 staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
Rabbit Anti-EIF6 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS4510370

Other Notes

Small volumes of anti-EIF6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF6. It may not necessarily be applicable to this product.

NCBI GI #
3122258
NCBI GeneID
3692
NCBI Accession #
P56537.1
UniProt Primary Accession #
P56537
UniProt Secondary Accession #
O55135; Q3KRD8
UniProt Related Accession #
P56537
NCBI Official Full Name
Eukaryotic translation initiation factor 6
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 6
NCBI Official Symbol
EIF6
NCBI Official Synonym Symbols
CAB; EIF3A; eIF-6; p27BBP; ITGB4BP; b(2)gcn; p27(BBP)
UniProt Protein Name
Eukaryotic translation initiation factor 6
UniProt Synonym Protein Names
B(2)GCN homolog; B4 integrin interactor; CAB; p27(BBP)
Protein Family
Translation initiation factor
UniProt Gene Name
EIF6
UniProt Entry Name
IF6_HUMAN
NCBI Protein Information
eukaryotic translation initiation factor 6; EIF6; eIF-6; B4 integrin interactor; p27 beta-4 integrin-binding protein; eukaryotic translation initiation factor 3A

NCBI Summary for EIF6

Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
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UniProt Comments for EIF6

EIF6: eukaryotic translation initiation factor 6. Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex.

Protein type: Translation; Translation initiation; Nucleolus

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: nucleoplasm; cytoplasm; nucleolus; lamin filament; nucleus

Molecular Function: protein binding; translation initiation factor activity; ribosome binding; ribosomal large subunit binding

Biological Process: translational initiation; ribosomal large subunit biogenesis and assembly; mature ribosome assembly; ribosome export from nucleus
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Research Articles on EIF6

1. SBDS protein facilitates the release of eIF6, a factor that prevents ribosome joining.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EIF6 antibody

 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Ribosome Biogenesis In Eukaryotes Pathway antibodies  Ribosome Biogenesis In Eukaryotes Pathway Diagram
 Translation Factors Pathway antibodies  Translation Factors Pathway Diagram

Diseases associated with anti-EIF6 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >4 publications with EIF6 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >3 publications with EIF6 and Cell Transformation, Neoplastic
 Congenital Abnormalities Antibodies  >2 publications with EIF6 and Congenital Abnormalities
 Liver Diseases Antibodies  >2 publications with EIF6 and Liver Diseases
 Neoplasm Metastasis Antibodies  >1 publications with EIF6 and Neoplasm Metastasis
 Edema Antibodies  >1 publications with EIF6 and Edema
 Inflammation Antibodies  >1 publications with EIF6 and Inflammation
 Liver Neoplasms Antibodies  >1 publications with EIF6 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with EIF6 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >1 publications with EIF6 and Breast Neoplasms

Organs/Tissues associated with anti-EIF6 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >8 publications with EIF6 and Bone Marrow
 Bone Antibodies  >8 publications with EIF6 and Bone
 Blood Antibodies  >7 publications with EIF6 and Blood
 Embryonic Tissue Antibodies  >6 publications with EIF6 and Embryonic Tissue
 Liver Antibodies  >5 publications with EIF6 and Liver
 Eye Antibodies  >4 publications with EIF6 and Eye
 Lung Antibodies  >4 publications with EIF6 and Lung
 Intestine Antibodies  >3 publications with EIF6 and Intestine
 Nerve Antibodies  >3 publications with EIF6 and Nerve
 Umbilical Cord Antibodies  >2 publications with EIF6 and Umbilical Cord
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