FK506 Binding Protein 4 (FKBP4) Antibody – Rabbit Polyclonal

FKBP4: Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly.

Protein type: Chaperone; Isomerase; EC 5.2.1.8

Cellular Component: nucleoplasm; microtubule; endoplasmic reticulum membrane; neuron projection; protein complex; mitochondrion; cell soma; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol

Molecular Function: FK506 binding; peptidyl-prolyl cis-trans isomerase activity; GTP binding; heat shock protein binding; phosphoprotein binding; tau protein binding; copper-dependent protein binding; ATP binding; glucocorticoid receptor binding

Biological Process: prostate gland development; male sex differentiation; steroid hormone receptor complex assembly; protein peptidyl-prolyl isomerization; protein complex localization; negative regulation of microtubule polymerization; negative regulation of microtubule polymerization or depolymerization; androgen receptor signaling pathway; copper ion transport; reproductive structure development; embryo implantation