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GABRB1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9401148

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a… More details

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Product Overview

Online Datasheet in PDF
Product Name
GABRB1, Polyclonal Antibody
Full Product Name
GABRB1 (Ab-434) Antibody
Product Gene Name
anti-GABRB1 antibody
Product Synonym Names
GABA(A) receptor; GABA(A)R beta-1; GBRB1; GABA-RB
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1.0 mg/ml (lot specific)
Specificity
The antibody detects endogenous level of total GABRB1 protein.
Preparation and Storage
Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.
Molecular Weight
10,151 Da
OMIM
137190
3D Structure
ModBase 3D Structure for P18505
Immunogen Type
Peptide-KLH
Immunogen Description
Peptide sequence around aa.432~436 (R-A-S-Q-L) derived from Human GABRB1.
Target Name
GABRB1

Product Categories/Family for anti-GABRB1 antibody

Total protein Ab
Applications Tested/Suitable for anti-GABRB1 antibody
Western Blot (WB)
Application Notes for anti-GABRB1 antibody
Western blotting: 1:500~1:1000

Western Blot (WB) of anti-GABRB1 antibody

Western blot analysis of extracts from PC12 cells using GABRB1(Ab-434) Antibody and the same antibody preincubated with blocking peptide.
Rabbit Anti-GABRB1 Polyclonal Antibody – Cat# MBS9401148

Other Notes

Small volumes of anti-GABRB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GABRB1 purchase

MBS9401148 is an antibody targeting GABRB1. Also known as GABRB1 (Ab-434) Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GABRB1. It may not necessarily be applicable to this product.

NCBI GI #
194097327
NCBI GeneID
2560
NCBI Accession #
NP_000803.2
UniProt Primary Accession #
P18505
UniProt Secondary Accession #
Q16166; Q8TBK3; B2R6U7; D6REL3
UniProt Related Accession #
P18505
GenBank Nucleotide #
NM_000812.3
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit beta-1
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) A receptor, beta 1
NCBI Official Symbol
GABRB1
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit beta-1
UniProt Synonym Protein Names
GABA(A) receptor subunit beta-1
Protein Family
Gamma-aminobutyric acid receptor
UniProt Gene Name
GABRB1
UniProt Entry Name
GBRB1_HUMAN
NCBI Protein Information
gamma-aminobutyric acid receptor subunit beta-1

NCBI Summary for GABRB1

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq, Jul 2008]
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UniProt Comments for GABRB1

GABRB1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily.

Protein type: Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: chloride channel activity; GABA-A receptor activity; ligand-gated ion channel activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; ion transport; signal transduction; transmembrane transport
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Research Articles on GABRB1

1. Both mRNA and protein of GABAB receptor subunits, GABAB1 and GABAB2, were co-expressed in cultured human RPE cells; GABAB receptors regulate the [Ca2+]i via a pertussis toxin-sensitive Gi/o-protein pathway and a phospholipase C pathway

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GABRB1 antibody

 Reference Product  PubMed Publications
 GABRA4 antibody  >15 publications with GABRB1 and GABRA4
 GABRA2 antibody  >12 publications with GABRB1 and GABRA2
 GABRB3 antibody  >10 publications with GABRB1 and GABRB3
 GABRB2 antibody  >10 publications with GABRB1 and GABRB2
 GABRA5 antibody  >9 publications with GABRB1 and GABRA5
 GABRA1 antibody  >8 publications with GABRB1 and GABRA1
 GABRG2 antibody  >4 publications with GABRB1 and GABRG2
 GABRA6 antibody  >3 publications with GABRB1 and GABRA6
 GABRG3 antibody  >2 publications with GABRB1 and GABRG3
 GABRA3 antibody  >1 publications with GABRB1 and GABRA3

Pathways associated with anti-GABRB1 antibody

 Products by Pathway  Pathway Diagram
 GABA A Receptor Activation Pathway antibodies  GABA A Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-GABRB1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with GABRB1 and Nervous System Diseases
 Anxiety Disorders Antibodies  >4 publications with GABRB1 and Anxiety Disorders
 Brain Diseases Antibodies  >4 publications with GABRB1 and Brain Diseases
 Central Nervous System Diseases Antibodies  >4 publications with GABRB1 and Central Nervous System Diseases
 Autistic Disorder Antibodies  >4 publications with GABRB1 and Autistic Disorder
 Cognition Disorders Antibodies  >3 publications with GABRB1 and Cognition Disorders
 Epilepsy Antibodies  >3 publications with GABRB1 and Epilepsy
 Disease Models, Animal Antibodies  >3 publications with GABRB1 and Disease Models, Animal
 Movement Disorders Antibodies  >2 publications with GABRB1 and Movement Disorders
 Memory Disorders Antibodies  >1 publications with GABRB1 and Memory Disorders

Organs/Tissues associated with anti-GABRB1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >29 publications with GABRB1 and Brain
 Embryonic Tissue Antibodies  >1 publications with GABRB1 and Embryonic Tissue
 Eye Antibodies  >1 publications with GABRB1 and Eye
 Heart Antibodies  >1 publications with GABRB1 and Heart
 Kidney Antibodies  >1 publications with GABRB1 and Kidney
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