• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GAP-43 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9243732

This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. More details

$475 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GAP-43, Polyclonal Antibody
Full Product Name
GAP-43 Polyclonal Antibody
Product Gene Name
anti-GAP-43 antibody
Product Synonym Gene Name
GAP43
Product Synonym Names
GAP43; Neuromodulin; Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
24,803 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (115342151..115440334). Location: 3q13.1-q13.2
OMIM
162060
3D Structure
ModBase 3D Structure for P17677
Applications Tested/Suitable for anti-GAP-43 antibody
Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)

Immunohistochemistry (IHC) of anti-GAP-43 antibody

Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Rabbit Anti-GAP-43 Polyclonal Antibody – Cat# MBS9243732

Western Blot (WB) of anti-GAP-43 antibody

Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Rabbit Anti-GAP-43 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9243732

Other Notes

Small volumes of anti-GAP-43 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GAP-43 purchase

MBS9243732 is an antibody targeting GAP-43. Also known as GAP-43 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GAP-43. It may not necessarily be applicable to this product.

NCBI GI #
194248057
NCBI GeneID
2596
NCBI Accession #
NP_001123536.1
UniProt Primary Accession #
P17677
UniProt Secondary Accession #
A8K0Y4
UniProt Related Accession #
P17677
GenBank Nucleotide #
NM_001130064.1
NCBI Official Full Name
neuromodulin isoform 1
NCBI Official Synonym Full Names
growth associated protein 43
NCBI Official Symbol
GAP43
NCBI Official Synonym Symbols
B-50; PP46
UniProt Protein Name
Neuromodulin
UniProt Synonym Protein Names
Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46
Protein Family
Neuromodulin
UniProt Gene Name
GAP43
UniProt Entry Name
NEUM_HUMAN
NCBI Protein Information
neuromodulin; protein F1; neural phosphoprotein B-50; growth-associated protein 43; axonal membrane protein GAP-43; calmodulin-binding protein P-57; nerve growth-related peptide GAP43; neuron growth-associated protein 43

NCBI Summary for GAP-43

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for GAP-43

GAP43: This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface

Chromosomal Location of Human Ortholog: 3q13.31

Cellular Component: filopodium membrane; axon; cytoplasm; postsynaptic density; plasma membrane; cell junction

Molecular Function: calmodulin binding; protein binding

Biological Process: cell fate commitment; glial cell differentiation; tissue regeneration; regulation of growth; axon choice point recognition; protein kinase C activation; response to wounding; regulation of filopodium formation
Show more

Research Articles on GAP-43

1. Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GAP-43 antibody

 Products by Pathway  Pathway Diagram
 Glial Cell Differentiation Pathway antibodies  Glial Cell Differentiation Pathway Diagram
 N-cadherin Signaling Events Pathway antibodies  N-cadherin Signaling Events Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram

Diseases associated with anti-GAP-43 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >103 publications with GAP-43 and Nervous System Diseases
 Disease Models, Animal Antibodies  >52 publications with GAP-43 and Disease Models, Animal
 Brain Diseases Antibodies  >43 publications with GAP-43 and Brain Diseases
 Cardiovascular Diseases Antibodies  >35 publications with GAP-43 and Cardiovascular Diseases
 Neoplasms Antibodies  >29 publications with GAP-43 and Neoplasms
 Death Antibodies  >27 publications with GAP-43 and Death
 Heart Diseases Antibodies  >24 publications with GAP-43 and Heart Diseases
 Inflammation Antibodies  >19 publications with GAP-43 and Inflammation
 Nerve Degeneration Antibodies  >18 publications with GAP-43 and Nerve Degeneration
 Pain Antibodies  >18 publications with GAP-43 and Pain

Organs/Tissues associated with anti-GAP-43 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >231 publications with GAP-43 and Nerve
 Brain Antibodies  >194 publications with GAP-43 and Brain
 Embryonic Tissue Antibodies  >27 publications with GAP-43 and Embryonic Tissue
 Eye Antibodies  >26 publications with GAP-43 and Eye
 Bone Antibodies  >15 publications with GAP-43 and Bone
 Vascular Antibodies  >12 publications with GAP-43 and Vascular
 Lung Antibodies  >2 publications with GAP-43 and Lung
 Connective Tissue Antibodies  >1 publications with GAP-43 and Connective Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000