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GAP43 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8572891

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective… More details

$380 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GAP43, Polyclonal Antibody
Full Product Name
GAP43 Polyclonal Antibody
Product Gene Name
anti-GAP43 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
24kDa; 28kDa
OMIM
162060
3D Structure
ModBase 3D Structure for P17677
Immunogen
Recombinant protein of human GAP43 (NP_002036.1).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GAP43 antibody
Western Blot (WB)
Application Notes for anti-GAP43 antibody
WB: 1:500-1:2000

Other Notes

Small volumes of anti-GAP43 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GAP43 purchase

MBS8572891 is an antibody targeting GAP43. Also known as GAP43 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GAP43. It may not necessarily be applicable to this product.

NCBI GI #
194248057
NCBI GeneID
2596
NCBI Accession #
NP_001123536.1
UniProt Primary Accession #
P17677
UniProt Related Accession #
P17677
GenBank Nucleotide #
NP_001123536.1
NCBI Official Full Name
neuromodulin isoform 1
NCBI Official Synonym Full Names
growth associated protein 43
NCBI Official Symbol
GAP43
NCBI Official Synonym Symbols
B-50; PP46
UniProt Protein Name
Neuromodulin
UniProt Synonym Protein Names
Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46
Protein Family
Neuromodulin
UniProt Gene Name
GAP43
UniProt Entry Name
NEUM_HUMAN
NCBI Protein Information
neuromodulin

UniProt Comments for GAP43

GAP43: This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface

Chromosomal Location of Human Ortholog: 3q13.31

Cellular Component: filopodium membrane; axon; cytoplasm; postsynaptic density; plasma membrane; cell junction

Molecular Function: calmodulin binding; protein binding

Biological Process: cell fate commitment; glial cell differentiation; tissue regeneration; regulation of growth; axon choice point recognition; protein kinase C activation; response to wounding; regulation of filopodium formation
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Research Articles on GAP43

1. GAP43 is an independent predictor of non-small cell lung cancer brain metastasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GAP43 antibody

 Products by Pathway  Pathway Diagram
 Glial Cell Differentiation Pathway antibodies  Glial Cell Differentiation Pathway Diagram
 N-cadherin Signaling Events Pathway antibodies  N-cadherin Signaling Events Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram

Diseases associated with anti-GAP43 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >103 publications with GAP43 and Nervous System Diseases
 Disease Models, Animal Antibodies  >52 publications with GAP43 and Disease Models, Animal
 Brain Diseases Antibodies  >43 publications with GAP43 and Brain Diseases
 Cardiovascular Diseases Antibodies  >35 publications with GAP43 and Cardiovascular Diseases
 Neoplasms Antibodies  >29 publications with GAP43 and Neoplasms
 Death Antibodies  >27 publications with GAP43 and Death
 Heart Diseases Antibodies  >24 publications with GAP43 and Heart Diseases
 Inflammation Antibodies  >19 publications with GAP43 and Inflammation
 Nerve Degeneration Antibodies  >18 publications with GAP43 and Nerve Degeneration
 Pain Antibodies  >18 publications with GAP43 and Pain

Organs/Tissues associated with anti-GAP43 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >231 publications with GAP43 and Nerve
 Brain Antibodies  >194 publications with GAP43 and Brain
 Embryonic Tissue Antibodies  >27 publications with GAP43 and Embryonic Tissue
 Eye Antibodies  >26 publications with GAP43 and Eye
 Bone Antibodies  >15 publications with GAP43 and Bone
 Vascular Antibodies  >12 publications with GAP43 and Vascular
 Lung Antibodies  >2 publications with GAP43 and Lung
 Connective Tissue Antibodies  >1 publications with GAP43 and Connective Tissue
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