GATA6 Antibody – Rabbit Polyclonal

GATA6: Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Transcription factor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 18q11.1-q11.2

Cellular Component: nucleoplasm; transcription factor complex; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; zinc ion binding; chromatin binding; protein kinase binding; transcription factor activity; transcription factor binding

Biological Process: response to drug; transcription from RNA polymerase II promoter; cardiac muscle hypertrophy; organ formation; endodermal cell fate determination; in utero embryonic development; male gonad development; negative regulation of transcription from RNA polymerase II promoter; liver development; cardiac muscle cell differentiation; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; positive regulation of angiogenesis; response to estrogen stimulus; phospholipid metabolic process; positive regulation of cardioblast differentiation; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; blood coagulation; tube morphogenesis; negative regulation of transcription, DNA-dependent; positive regulation of cardiac muscle cell proliferation; negative regulation of apoptosis

Disease: Conotruncal Heart Malformations; Atrial Septal Defect 9; Heart Defects, Congenital, And Other Congenital Anomalies; Atrioventricular Septal Defect 5; Tetralogy Of Fallot