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GCC2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9210728

The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Alternative splicing results in… More details

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Product Overview

Online Datasheet in PDF
Product Name
GCC2, Polyclonal Antibody
Full Product Name
GCC2 Antibody (C-term)
Product Gene Name
anti-GCC2 antibody
Product Synonym Names
GRIP and coiled-coil domain-containing protein 2; 185 kDa Golgi coiled-coil protein; GCC185; CLL-associated antigen KW-11; CTCL tumor antigen se1-1; Ran-binding protein 2-like 4; RanBP2L4; Renal carcinoma antigen NY-REN-53; GCC2; KIAA0336; RANBP2L4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, mouse (Predicted Reactivity: Rat)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purity/Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Specificity
This GCC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1581-1609 amino acids from the C-terminal region of human GCC2.
Preparation and Storage
Maintain refrigerated at 2-8 degree for up to 2 weeks. For long term storage store at -20 degree in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
GCC2 peptide (MBS9217477) is used for blocking the activity of GCC2 antibody (MBS9210728)
Molecular Weight
Calculated MW: 195910
Immunogen Sequence Positions
1581-1609
OMIM
612711
3D Structure
ModBase 3D Structure for Q8IWJ2
Function
Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.
Cellular Location
Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
Tissue Location
Ubiquitous

Product Categories/Family for anti-GCC2 antibody

Signal Transduction
Applications Tested/Suitable for anti-GCC2 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC-P)
Application Notes for anti-GCC2 antibody
WB~~1:1000
IHC-P~~1:50~100

Western Blot (WB) of anti-GCC2 antibody

GCC2 Antibody (C-term) (MBS9210728) western blot analysis in mouse stomach tissue lysates (15ug/lane).This demonstrates the GCC2 antibody detected GCC2 protein (arrow).
Rabbit Anti-GCC2 Polyclonal Antibody – Cat# MBS9210728

Immunohistochemistry (IHC) of anti-GCC2 antibody

GCC2 antibody (C-term) (MBS9210728) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GCC2 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-GCC2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9210728

Product References and Citations for anti-GCC2 antibody

Houghton, F.J., et al. Cell 138(4):787-794(2009)
Hayes, G.L., et al. Mol. Biol. Cell 20(1):209-217(2009)
Burguete, A.S., et al. Cell 132(2):286-298(2008)
Efimov, A., et al. Dev. Cell 12(6):917-930(2007)
Derby, M.C., et al. Traffic 8(6):758-773(2007)

Other Notes

Small volumes of anti-GCC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GCC2 purchase

MBS9210728 is an antibody targeting GCC2. Also known as GCC2 Antibody (C-term). Reactive in Human, mouse (Predicted Reactivity: Rat). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GCC2. It may not necessarily be applicable to this product.

NCBI GI #
31563507
NCBI GeneID
9648
NCBI Accession #
NP_852118.1
UniProt Primary Accession #
Q8IWJ2
UniProt Secondary Accession #
O15045; Q4ZG46; Q8TDH3; Q9H2G8; A6H8X8
UniProt Related Accession #
Q8IWJ2
GenBank Nucleotide #
NM_181453.3
NCBI Official Full Name
GRIP and coiled-coil domain-containing protein 2
NCBI Official Synonym Full Names
GRIP and coiled-coil domain containing 2
NCBI Official Symbol
GCC2
NCBI Official Synonym Symbols
REN53; GCC185; RANBP2L4
UniProt Protein Name
GRIP and coiled-coil domain-containing protein 2
UniProt Synonym Protein Names
185 kDa Golgi coiled-coil protein; GCC185; CLL-associated antigen KW-11; CTCL tumor antigen se1-1; Ran-binding protein 2-like 4; RanBP2L4; Renal carcinoma antigen NY-REN-53
UniProt Gene Name
GCC2
UniProt Synonym Gene Names
KIAA0336; RANBP2L4; GCC185; RanBP2L4
UniProt Entry Name
GCC2_HUMAN
NCBI Protein Information
GRIP and coiled-coil domain-containing protein 2

UniProt Comments for GCC2

GCC2: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 2q12.3

Cellular Component: nucleoplasm; Golgi apparatus; membrane; cytoplasm; trans-Golgi network; nucleus

Molecular Function: identical protein binding; protein binding

Biological Process: microtubule organizing center organization and biogenesis; protein targeting to lysosome; protein localization in Golgi apparatus; Golgi to plasma membrane protein transport; protein targeting to Golgi; retrograde transport, endosome to Golgi
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Research Articles on GCC2

1. Deletion of the ARL4A-interacting region of GCC185 results in inability to maintain Golgi structure and modulate endosome-to-Golgi transport.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GCC2 antibody

 Reference Product  PubMed Publications
 ARL1 antibody  >5 publications with GCC2 and ARL1
 GOLGA4 antibody  >2 publications with GCC2 and GOLGA4
 STX6 antibody  >1 publications with GCC2 and STX6
 VTI1A antibody  >1 publications with GCC2 and VTI1A
 STX10 antibody  >1 publications with GCC2 and STX10
 RAB6A antibody  >1 publications with GCC2 and RAB6A

Organs/Tissues associated with anti-GCC2 antibody

 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >1 publications with GCC2 and Placenta
 Eye Antibodies  >1 publications with GCC2 and Eye
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