• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GLYM Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9520133

This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine… More details

$255 / 0.04 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GLYM, Polyclonal Antibody
Full Product Name
GLYM Antibody
Product Gene Name
anti-GLYM antibody
Product Synonym Names
GLYM
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human, Rat, Mouse
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1mg/ml (lot specific)
Specificity
This antibody detects endogenous levels of GLYM at Human
Preparation and Storage
Store at -20 degree C/1 year
Molecular Weight
504
OMIM
138450
3D Structure
ModBase 3D Structure for P34897
Immunogen
Synthesized peptide derived from human GLYM AA range: 122-172
Modification
Unmodified/Total

Product Categories/Family for anti-GLYM antibody

Primary Antibodies
Applications Tested/Suitable for anti-GLYM antibody
Western Blot (WB)
Application Notes for anti-GLYM antibody
WB: 1:500-2000

Western Blot (WB) of anti-GLYM antibody

Western blot analysis of lysates from A549 cells, primary antibody was diluted at 1:1000, 4 degree over night
Rabbit Anti-GLYM Polyclonal Antibody – Cat# MBS9520133

Other Notes

Small volumes of anti-GLYM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLYM purchase

MBS9520133 is an antibody targeting GLYM. Also known as GLYM Antibody. Reactive in Human, Rat, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GLYM. It may not necessarily be applicable to this product.

NCBI GI #
6226865
NCBI GeneID
6472
NCBI Accession #
P34897.3
UniProt Primary Accession #
P34897
UniProt Secondary Accession #
O00740; Q8N1A5; B7Z9F1; E7EQ19; E7EU43
UniProt Related Accession #
P34897
NCBI Official Full Name
Serine hydroxymethyltransferase, mitochondrial
NCBI Official Synonym Full Names
serine hydroxymethyltransferase 2 (mitochondrial)
NCBI Official Symbol
SHMT2
NCBI Official Synonym Symbols
GLYA; SHMT; HEL-S-51e
UniProt Protein Name
Serine hydroxymethyltransferase, mitochondrial
UniProt Synonym Protein Names
Glycine hydroxymethyltransferase; Serine methylase
UniProt Gene Name
SHMT2
UniProt Synonym Gene Names
SHMT
UniProt Entry Name
GLYM_HUMAN
NCBI Protein Information
serine hydroxymethyltransferase, mitochondrial; GLY A+; serine aldolase; serine methylase; threonine aldolase; serine hydroxymethylase; glycine hydroxymethyltransferase; epididymis secretory sperm binding protein Li 51e; glycine auxotroph A, human complem

UniProt Comments for GLYM

SHMT2: Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - glycine, serine and threonine; Methyltransferase; Energy Metabolism - methane; Cofactor and Vitamin Metabolism - one carbon pool by folate; Mitochondrial; EC 2.1.2.1; Other Amino Acids Metabolism - cyanoamino acid

Chromosomal Location of Human Ortholog: 12q12-q14

Cellular Component: microtubule cytoskeleton; mitochondrion; mitochondrial matrix; mitochondrial inner membrane; mitochondrial intermembrane space

Molecular Function: L-allo-threonine aldolase activity; identical protein binding; amino acid binding; glycine hydroxymethyltransferase activity; chromatin binding; pyridoxal phosphate binding

Biological Process: L-serine biosynthetic process; positive regulation of cell proliferation; one-carbon compound metabolic process; glycine biosynthetic process from serine; protein homotetramerization
Show more

Research Articles on GLYM

1. The present study not only describes individual genetic variation that directly affects SHMT1 and SHMT2 activity, but provided insight into the overall regulation of the Folate and Methionine Cycles.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GLYM antibody

 Reference Product  PubMed Publications
 TYMS antibody  >2 publications with GLYM and TYMS
 MTHFR antibody  >1 publications with GLYM and MTHFR
 ATIC antibody  >1 publications with GLYM and ATIC

Pathways associated with anti-GLYM antibody

 Products by Pathway  Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 C1-unit Interconversion, Eukaryotes Pathway antibodies  C1-unit Interconversion, Eukaryotes Pathway Diagram
 C1-unit Interconversion, Eukaryotes Pathway antibodies  C1-unit Interconversion, Eukaryotes Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Cyanoamino Acid Metabolism Pathway antibodies  Cyanoamino Acid Metabolism Pathway Diagram
 Cyanoamino Acid Metabolism Pathway antibodies  Cyanoamino Acid Metabolism Pathway Diagram
 Glycine Metabolism Pathway antibodies  Glycine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram

Diseases associated with anti-GLYM antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with GLYM and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with GLYM and Brain Diseases

Organs/Tissues associated with anti-GLYM antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with GLYM and Lung
 Blood Antibodies  >2 publications with GLYM and Blood
 Liver Antibodies  >2 publications with GLYM and Liver
 Brain Antibodies  >2 publications with GLYM and Brain
 Adipose Tissue Antibodies  >1 publications with GLYM and Adipose Tissue
 Vascular Antibodies  >1 publications with GLYM and Vascular
 Ovary Antibodies  >1 publications with GLYM and Ovary
 Connective Tissue Antibodies  >1 publications with GLYM and Connective Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000