HTR1B Antibody – Rabbit Polyclonal

Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Subunit Structure: Homodimer. Heterodimer with HTR1D.
Post-translational Modifications: Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. Palmitoylated.
Similarity: Ligands are bound in a hydrophobic pocket formed by the transmembrane helices. Belongs to the G-protein coupled receptor 1 family.

Small volumes of anti-HTR1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9606297 is an antibody targeting HTR1B. Also known as HTR1B Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.