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IL1A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9607546

IL-1 alpha is a pro-inflammatory cytokine produced by activated monocytes, lymphocytes and epithelial cells (1). IL-1 alpha is synthesized as an active precursor protein that appears tobe cleaved by cytosolic proteases into its mature form (1,2). Often,… More details

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Product Documentation
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
IL1A, Polyclonal Antibody
Full Product Name
IL1A Antibody
Product Gene Name
anti-IL1A antibody
Product Synonym Names
BAF; FAF; Hematopoietin 1; Hematopoietin-1; IL 1 alpha; IL 1A; IL-1 alpha; Il-1a; IL1 ALPHA; IL1; IL1A; IL1A_HUMAN; IL1F1; Interleukin 1 alpha; Interleukin-1 alpha; Interleukin1 alpha; LAF; LEM; Preinterleukin 1 alpha; Pro interleukin 1 alpha
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Peptide affinity purification
Concentration
~1mg/ml (lot specific)
Specificity
IL1 alpha antibody detects endogenous levels of total IL1 alpha
Preparation and Storage
Store at -20°C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
IL1 alpha peptide (MBS9626262) is used for blocking the activity of IL1 alpha antibody (MBS9607546)
Molecular Weight
31 kDa
3D Structure
ModBase 3D Structure for P01583
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human IL1 alpha, corresponding to a region within N-terminal amino acids.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-IL1A antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-IL1A antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
EIA(peptide): 1:20000-1:40000
The optimal dilution should be determined by the end user.
IMPORTANT: For western blots, incubate membrane with diluted antibody in 5% w/v milk , 1X TBS, 0.1% Tween®20 at 4°C with gentle shaking, overnight.

Western Blot (WB) of anti-IL1A antibody

Western blot analysis of extracts from mouse brain, using IL1A Antibody.
Rabbit Anti-IL1A Polyclonal Antibody – Cat# MBS9607546

Immunohistochemistry (IHC) of anti-IL1A antibody

MBS9607546 at 1/100 staining Human uterus tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-IL1A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9607546

Other Notes

Small volumes of anti-IL1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL1A purchase

MBS9607546 is an antibody targeting IL1A. Also known as IL1A Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL1A. It may not necessarily be applicable to this product.

NCBI GI #
27894330
NCBI GeneID
3552
NCBI Accession #
NP_000566.3
UniProt Primary Accession #
P01583
UniProt Secondary Accession #
Q53QF9; Q7RU02
UniProt Related Accession #
P01583
GenBank Nucleotide #
NM_000575.4
NCBI Official Full Name
interleukin-1 alpha
NCBI Official Synonym Full Names
interleukin 1 alpha
NCBI Official Symbol
IL1A
NCBI Official Synonym Symbols
IL1; IL-1A; IL1F1; IL1-ALPHA
UniProt Protein Name
Interleukin-1 alpha
UniProt Synonym Protein Names
Hematopoietin-1
Protein Family
Interleukin
UniProt Gene Name
IL1A
UniProt Synonym Gene Names
IL1F1; IL-1 alpha
NCBI Protein Information
interleukin-1 alpha

NCBI Summary for IL1A

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL1A

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
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Research Articles on IL1A

1. Meta-analysis suggests that the IL-1B rs16944 polymorphism is a susceptibility risk factor for febrile seizures in Caucasian and Asian populations. The IL-1B rs1143627, IL-1B rs1143634, and IL-1A rs1800587 polymorphisms are not associated with febrile seizure risk.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL1A antibody

 Reference Product  PubMed Publications
 IL1B antibody  >157 publications with IL1A and IL1B
 IL6 antibody  >75 publications with IL1A and IL6
 IL8 antibody  >26 publications with IL1A and IL8
 IL1R1 antibody  >13 publications with IL1A and IL1R1
 CSF2 antibody  >7 publications with IL1A and CSF2
 MYD88 antibody  >3 publications with IL1A and MYD88
 IL1R2 antibody  >3 publications with IL1A and IL1R2

Pathways associated with anti-IL1A antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with anti-IL1A antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >59 publications with IL1A and Inflammation
 Necrosis Antibodies  >45 publications with IL1A and Necrosis
 Neoplasms Antibodies  >38 publications with IL1A and Neoplasms
 Skin Diseases Antibodies  >27 publications with IL1A and Skin Diseases
 Cardiovascular Diseases Antibodies  >20 publications with IL1A and Cardiovascular Diseases
 Lung Diseases Antibodies  >15 publications with IL1A and Lung Diseases
 Kidney Diseases Antibodies  >8 publications with IL1A and Kidney Diseases
 Heart Diseases Antibodies  >6 publications with IL1A and Heart Diseases
 Drug Toxicity Antibodies  >6 publications with IL1A and Drug Toxicity
 Pain Antibodies  >5 publications with IL1A and Pain

Organs/Tissues associated with anti-IL1A antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >18 publications with IL1A and Skin
 Lung Antibodies  >13 publications with IL1A and Lung
 Vascular Antibodies  >11 publications with IL1A and Vascular
 Brain Antibodies  >10 publications with IL1A and Brain
 Testis Antibodies  >4 publications with IL1A and Testis
 Mouth Antibodies  >3 publications with IL1A and Mouth
 Cervix Antibodies  >2 publications with IL1A and Cervix
 Lymph Node Antibodies  >2 publications with IL1A and Lymph Node
 Intestine Antibodies  >1 publications with IL1A and Intestine
 Pharynx Antibodies  >1 publications with IL1A and Pharynx
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