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IL23R Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9607157

Description: The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL23R, Polyclonal Antibody
Full Product Name
IL23R Antibody
Product Gene Name
anti-IL23R antibody
Product Synonym Names
IL 23R; IL-23 receptor; IL-23R; Il23r; IL23R_HUMAN; Interleukin 23 receptor; Interleukin-23 receptor
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
IL23R antibody detects endogenous levels of total IL23R
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
IL23R peptide (MBS9625873) is used for blocking the activity of IL23R antibody (MBS9607157)
Molecular Weight
Observed: 69 kDa
Predicted: 72 kDa
3D Structure
ModBase 3D Structure for Q5VWK5
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human IL23R
Subcellular Location
Cell Membrane
Tissue Specificity
Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Rabbit, Dog
Similarity
Pig (88%), Bovine (82%), Horse (88%), Sheep (88%), Rabbit (80%), Dog (94%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-IL23R antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-IL23R antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-IL23R antibody

MBS9607157 at 1/100 staining Human liver cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-IL23R Polyclonal Antibody – Cat# MBS9607157

Western Blot (WB) of anti-IL23R antibody

Western blot analysis of K562 whole cell lysates, using IL23R Antibody. The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-IL23R Polyclonal Antibody, Western Blot (WB) – Cat# MBS9607157

Other Notes

Small volumes of anti-IL23R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL23R purchase

MBS9607157 is an antibody targeting IL23R. Also known as IL23R Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IL23R. It may not necessarily be applicable to this product.

NCBI GI #
24430212
NCBI GeneID
149233
NCBI Accession #
NP_653302.2
UniProt Primary Accession #
Q5VWK5
UniProt Secondary Accession #
Q4VGP1; Q4VGP2; Q4VGP3; Q4VGP4; Q4VGP5; Q4VGP6; Q5VWK7; Q8IW84; Q8NFQ9; Q96AS1; C9JGX4
UniProt Related Accession #
Q5VWK5
GenBank Nucleotide #
NM_144701.2
NCBI Official Full Name
interleukin-23 receptor
NCBI Official Synonym Full Names
interleukin 23 receptor
NCBI Official Symbol
IL23R
UniProt Protein Name
Interleukin-23 receptor
Protein Family
Interleukin-23 receptor
UniProt Gene Name
IL23R
UniProt Synonym Gene Names
IL-23 receptor; IL-23R
NCBI Protein Information
interleukin-23 receptor

NCBI Summary for IL23R

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL23R

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
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Research Articles on IL23R

1. The IL23R gene rs10889677 A allele confers increased risk of ankylosing spondylitis (AS) in Europeans, but its role in Asian populations needs further exploration.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IL23R antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-IL23R antibody

 Disease Name  Pubmed Publications
 Inflammatory Bowel Diseases Antibodies  >169 publications with IL23R and Inflammatory Bowel Diseases
 Crohn Disease Antibodies  >118 publications with IL23R and Crohn Disease
 Arthritis Antibodies  >84 publications with IL23R and Arthritis
 Colitis, Ulcerative Antibodies  >80 publications with IL23R and Colitis, Ulcerative
 Psoriasis Antibodies  >68 publications with IL23R and Psoriasis
 Inflammation Antibodies  >65 publications with IL23R and Inflammation
 Spondylitis, Ankylosing Antibodies  >49 publications with IL23R and Spondylitis, Ankylosing
 Inflammatory Bowel Disease 17 Antibodies  >38 publications with IL23R and Inflammatory Bowel Disease 17
 Necrosis Antibodies  >20 publications with IL23R and Necrosis
 Liver Diseases Antibodies  >6 publications with IL23R and Liver Diseases

Organs/Tissues associated with anti-IL23R antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >27 publications with IL23R and Skin
 Bone Marrow Antibodies  >5 publications with IL23R and Bone Marrow
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