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IMPA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8563507

MBS8563507 is an antibody targeting IMPA1. Reactive in HumanPredicted: Rat, Mouse. Host: Rabbit. Homo sapiens inositol(myo)-1(or 4)-monophosphatase 1 More details

$430 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IMPA1, Polyclonal Antibody
Full Product Name
IMPA1
Product Gene Name
anti-IMPA1 antibody
Product Synonym Names
Purified Rabbit Anti Human IMPA1 Polyclonal antibody; IMPA
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Predicted: Rat, Mouse
Form/Format
Already dissolved in sterile H2O with 1% BSA and 0.02% NaN3 and 50% Glycerol.
Purity/Purification
Purified By Antigen Affinity Column
Molecular Weight
30kDa
Immunogen
Recombinant fragment corresponding to 15-165aa of human IMPA1.
Cellular Localization
Cytoplasm
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-IMPA1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-IMPA1 antibody
ELISA: 1:20000-80000
WB: 1:200-1,000
IHC: 1:100-500

Product References and Citations for anti-IMPA1 antibody

Ohnishi T, Ohba H, Seo KC. et al. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. J Biol Chem. 282 (1):637-646 (2007)

Other Notes

Small volumes of anti-IMPA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IMPA1. It may not necessarily be applicable to this product.

NCBI GI #
16306980
NCBI GeneID
3612
NCBI Accession #
BC009565
UniProt Related Accession #
P29218
NCBI Official Full Name
Homo sapiens inositol(myo)-1(or 4)-monophosphatase 1, mRNA
NCBI Official Synonym Full Names
inositol monophosphatase 1
NCBI Official Symbol
IMPA1
NCBI Official Synonym Symbols
IMP; IMPA; MRT59
Protein Family
Inositol monophosphatase
NCBI Protein Information
inositol monophosphatase 1

NCBI Summary for IMPA1

This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
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Research Articles on IMPA1

1. Loss-of-function mutation in inositol monophosphatase 1 (IMPA1) results in abnormal synchrony in resting-state EEG. The IMPA1 mutation in the cohort of the current study was associated with severe intellectual disability and disruptive behavior

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IMPA1 antibody

 Products by Pathway  Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway antibodies  Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway Diagram
 Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway antibodies  Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram

Diseases associated with anti-IMPA1 antibody

 Disease Name  Pubmed Publications
 Seizures Antibodies  >4 publications with IMPA1 and Seizures
 Disease Models, Animal Antibodies  >2 publications with IMPA1 and Disease Models, Animal

Organs/Tissues associated with anti-IMPA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with IMPA1 and Brain
 Blood Antibodies  >5 publications with IMPA1 and Blood
 Kidney Antibodies  >4 publications with IMPA1 and Kidney
 Intestine Antibodies  >3 publications with IMPA1 and Intestine
 Skin Antibodies  >2 publications with IMPA1 and Skin
 Muscle Antibodies  >2 publications with IMPA1 and Muscle
 Eye Antibodies  >1 publications with IMPA1 and Eye
 Thyroid Antibodies  >1 publications with IMPA1 and Thyroid
 Testis Antibodies  >1 publications with IMPA1 and Testis
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