IPO7 Antibody – Rabbit Polyclonal

IPO7: a beta importin protein. Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin beta-1 subunit. A receptor for nuclear localization signals (NLS) that promotes translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.

Protein type: Nuclear import; Karyopherin; Nuclear export

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: nucleoplasm; membrane; cytoplasm; nuclear pore

Molecular Function: protein binding; histone binding; transporter activity; Ran GTPase binding

Biological Process: viral reproduction; protein import into nucleus; regulation of catalytic activity; innate immune response; signal transduction