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JAG1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9448106

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein… More details

$435 / 0.1 mL (Biotin) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
JAG1, Polyclonal Antibody
Full Product Name
JAG1 Conjugated Antibody
Product Gene Name
anti-JAG1 antibody
Product Synonym Names
AGS; AHD; AWS; HJ1; CD339; JAGL1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
Specificity
The antibody detects endogenous levels of total JAG1 protein.
Preparation and Storage
Store at 4 degree C for 6 months.
OMIM
phenotype 601920
3D Structure
ModBase 3D Structure for P78504
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human jagged 1
Conjugation
Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
Excitation Emission
AF350: 346nm/442nm
Applications Tested/Suitable for anti-JAG1 antibody
Most Applications
Application Notes for anti-JAG1 antibody
Suggested Dilution:
AF350 conjugated: most applications: 1:50-1:250
AF405 conjugated: most applications: 1:50-1:250
AF488 conjugated: most applications: 1:50-1:250
AF555 conjugated: most applications: 1:50-1:250
AF594 conjugated: most applications: 1:50-1:250
AF647 conjugated: most applications: 1:50-1:250
AF680 conjugated: most applications: 1:50-1:250
AF750 conjugated: most applications: 1:50-1:250
Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000

Other Notes

Small volumes of anti-JAG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JAG1 purchase

MBS9448106 is an antibody targeting JAG1. Also known as JAG1 Conjugated Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for JAG1. It may not necessarily be applicable to this product.

NCBI GI #
153945846
NCBI GeneID
3710
NCBI Accession #
NP_002215
UniProt Primary Accession #
P78504
UniProt Related Accession #
Q14573
GenBank Nucleotide #
NP_002215.2
NCBI Official Full Name
inositol 1,4,5-trisphosphate receptor type 3
NCBI Official Synonym Full Names
inositol 1,4,5-trisphosphate receptor type 3
NCBI Official Symbol
ITPR3
NCBI Official Synonym Symbols
IP3R; IP3R3
UniProt Protein Name
Protein jagged-1
UniProt Synonym Protein Names
CD_antigen: CD339
Protein Family
Protein jagged
UniProt Gene Name
JAG1
UniProt Synonym Gene Names
JAGL1; Jagged1; hJ1
UniProt Entry Name
JAG1_HUMAN
NCBI Protein Information
inositol 1,4,5-trisphosphate receptor type 3

NCBI Summary for JAG1

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
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UniProt Comments for JAG1

JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p12.1-p11.23

Cellular Component: membrane; apical part of cell; integral to plasma membrane; extracellular region; plasma membrane

Molecular Function: protein binding; growth factor activity; calcium ion binding; structural molecule activity; Notch binding

Biological Process: endothelial cell differentiation; nervous system development; Notch signaling pathway; positive regulation of myeloid cell differentiation; T cell mediated immunity; Notch receptor processing; auditory receptor cell differentiation; cell fate determination; negative regulation of fat cell differentiation; regulation of cell migration; regulation of cell proliferation; keratinocyte differentiation; myoblast differentiation; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; positive regulation of transcription from RNA polymerase II promoter; hemopoiesis; blood vessel remodeling; angiogenesis; positive regulation of Notch signaling pathway

Disease: Tetralogy Of Fallot; Alagille Syndrome 1
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Research Articles on JAG1

1. expression was decreased or absent in cholangiocytes from patients with cholestasis of sepsis and from those with severe alcoholic hepatitis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-JAG1 antibody

 Reference Product  PubMed Publications
 ORAI1 antibody  >3 publications with JAG1 and ORAI1
 STIM1 antibody  >3 publications with JAG1 and STIM1
 TRPC1 antibody  >3 publications with JAG1 and TRPC1
 TRPC3 antibody  >2 publications with JAG1 and TRPC3

Pathways associated with anti-JAG1 antibody

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Diseases associated with anti-JAG1 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4 publications with JAG1 and Carcinoma
 Disease Models, Animal Antibodies  >4 publications with JAG1 and Disease Models, Animal
 Diabetes Mellitus, Type 1 Antibodies  >4 publications with JAG1 and Diabetes Mellitus, Type 1
 Cardiovascular Diseases Antibodies  >3 publications with JAG1 and Cardiovascular Diseases
 Cognition Disorders Antibodies  >2 publications with JAG1 and Cognition Disorders
 Memory Disorders Antibodies  >2 publications with JAG1 and Memory Disorders
 Learning Disorders Antibodies  >2 publications with JAG1 and Learning Disorders
 Inflammation Antibodies  >2 publications with JAG1 and Inflammation
 Breast Neoplasms Antibodies  >1 publications with JAG1 and Breast Neoplasms
 Liver Diseases Antibodies  >1 publications with JAG1 and Liver Diseases

Organs/Tissues associated with anti-JAG1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with JAG1 and Brain
 Blood Antibodies  >6 publications with JAG1 and Blood
 Muscle Antibodies  >5 publications with JAG1 and Muscle
 Liver Antibodies  >4 publications with JAG1 and Liver
 Skin Antibodies  >3 publications with JAG1 and Skin
 Lymph Node Antibodies  >3 publications with JAG1 and Lymph Node
 Lymph Antibodies  >3 publications with JAG1 and Lymph
 Heart Antibodies  >3 publications with JAG1 and Heart
 Nerve Antibodies  >3 publications with JAG1 and Nerve
 Kidney Antibodies  >3 publications with JAG1 and Kidney
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