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KCNB1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2517006

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal… More details

$160 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KCNB1, Polyclonal Antibody
Full Product Name
KCNB1 Polyclonal Antibody
Product Gene Name
anti-KCNB1 antibody
Product Synonym Names
DRK1; KV2.1; h-DRK1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.9mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
95,878 Da
OMIM
600397
Immunogen
Synthetic peptide of human KCNB1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-KCNB1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-KCNB1 antibody
IHC: 1:25-1:100

Immunohistochemistry (IHC) of anti-KCNB1 antibody

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using KCNB1 Polyclonal Antibody at dilution 1:40
Rabbit Anti-KCNB1 Polyclonal Antibody – Cat# MBS2517006

Immunohistochemistry (IHC) of anti-KCNB1 antibody

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using KCNB1 Polyclonal Antibody at dilution 1:40
Rabbit Anti-KCNB1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2517006

Other Notes

Small volumes of anti-KCNB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNB1 purchase

MBS2517006 is an antibody targeting KCNB1. Also known as KCNB1 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNB1. It may not necessarily be applicable to this product.

NCBI GI #
84570020
NCBI GeneID
3745
NCBI Accession #
AAI10574.1
UniProt Secondary Accession #
Q14193
UniProt Related Accession #
Q14721
NCBI Official Full Name
KCNB1 protein, partial
NCBI Official Synonym Full Names
potassium channel, voltage gated Shab related subfamily B, member 1
NCBI Official Symbol
KCNB1
NCBI Official Synonym Symbols
DRK1; KV2.1; EIEE26; h-DRK1
UniProt Protein Name
Potassium voltage-gated channel subfamily B member 1
UniProt Synonym Protein Names
Delayed rectifier potassium channel 1; DRK1; h-DRK1; Voltage-gated potassium channel subunit Kv2.1
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNB1
UniProt Synonym Gene Names
DRK1; h-DRK1
UniProt Entry Name
KCNB1_HUMAN
NCBI Protein Information
potassium voltage-gated channel subfamily B member 1; delayed rectifier potassium channel 1; delayed rectifier potassium channel Kv2.1; h-DRK1 K(+) channel; potassium channel protein DRK1; potassium voltage-gated channel, Shab-related subfamily, member 1; voltage-gated potassium channel subunit Kv2.1

UniProt Comments for KCNB1

Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.

Protein type: Membrane protein, multi-pass; Channel, potassium; Channel, cation; Channel, ligand-gated; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20q13.2

Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; dendrite; plasma membrane; integral to membrane

Molecular Function: protein binding; outward rectifier potassium channel activity; delayed rectifier potassium channel activity; protein N-terminus binding

Biological Process: synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerization

Disease: Epileptic Encephalopathy, Early Infantile, 26
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Research Articles on KCNB1

1. This study identified a de novo missense mutation in KCNB1 that encodes the KV 2.1 voltage-gated potassium channel.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNB1 antibody

 Reference Product  PubMed Publications
 KCNG3 antibody  >5 publications with KCNB1 and KCNG3
 KCNV2 antibody  >4 publications with KCNB1 and KCNV2
 KCNH2 antibody  >2 publications with KCNB1 and KCNH2
 KCNS3 antibody  >2 publications with KCNB1 and KCNS3
 KCNG2 antibody  >2 publications with KCNB1 and KCNG2
 KCNV1 antibody  >2 publications with KCNB1 and KCNV1
 KCNAB3 antibody  >1 publications with KCNB1 and KCNAB3
 KCNG1 antibody  >1 publications with KCNB1 and KCNG1
 KCNH1 antibody  >1 publications with KCNB1 and KCNH1

Pathways associated with anti-KCNB1 antibody

 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway antibodies  Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Regulation Of Insulin Secretion Pathway antibodies  Regulation Of Insulin Secretion Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
 Taste Transduction Pathway antibodies  Taste Transduction Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with anti-KCNB1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >18 publications with KCNB1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >14 publications with KCNB1 and Heart Diseases
 Disease Models, Animal Antibodies  >13 publications with KCNB1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >11 publications with KCNB1 and Nervous System Diseases
 Brain Diseases Antibodies  >9 publications with KCNB1 and Brain Diseases
 Hypertrophy Antibodies  >6 publications with KCNB1 and Hypertrophy
 Lung Diseases Antibodies  >5 publications with KCNB1 and Lung Diseases
 Heart Defects, Congenital Antibodies  >3 publications with KCNB1 and Heart Defects, Congenital
 Liver Diseases Antibodies  >3 publications with KCNB1 and Liver Diseases
 Myocardial Infarction Antibodies  >2 publications with KCNB1 and Myocardial Infarction

Organs/Tissues associated with anti-KCNB1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >60 publications with KCNB1 and Brain
 Eye Antibodies  >4 publications with KCNB1 and Eye
 Uncharacterized Tissue Antibodies  >1 publications with KCNB1 and Uncharacterized Tissue
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