Klotho (KL) Antibody – Rabbit Polyclonal

Klotho: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. Defects in KL are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC). A severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients manifest recurrent, transient, painful swellings of the long bones associated with the radiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.2.1.31; Hydrolase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5|5 G3

Cellular Component: extracellular region; extracellular space; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane

Molecular Function: beta-glucosidase activity; beta-glucuronidase activity; fibroblast growth factor binding; fibroblast growth factor receptor binding; hydrolase activity; hydrolase activity, acting on glycosyl bonds; hydrolase activity, hydrolyzing O-glycosyl compounds; protein binding; signal transducer activity

Biological Process: acute inflammatory response; aging; calcium ion homeostasis; carbohydrate metabolic process; energy reserve metabolic process; fibroblast growth factor receptor signaling pathway; insulin receptor signaling pathway; metabolic process; negative regulation of systemic arterial blood pressure; norepinephrine biosynthetic process; positive regulation of bone mineralization