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anti-L-Plastin antibody :: Rabbit L-Plastin Polyclonal Antibody

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Catalog # MBS462234
Unit / Price
  0.1 mg  /  $285 +1 FREE 8GB USB
Testing Data
Product Name

L-Plastin, Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti L-Plastin/LCP1 Polyclonal antibody

Product Synonym Names
Rabbit anti-L-Plastin; Lymphocyte cytosolic protein-1 (LCP1); L-plastin; LC64P; CP64; Plastin 2 (PLS2)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat, Mouse
Specificity
This antibody recognizes ~70 kDa of L-plastin protein. It also reacts with human, mouse and rat. The other species are not tested.
Purity/Purification
The Rabbit IgG is purified by Epitope Affinity Purification.
Form/Format
This affinity purified antibody is supplied in sterile phosphatebuffered saline (pH7.2) containing antibody stabilizer
Concentration
Size: 100 ug/200 ul (lot specific)
Antigen Preparation
A synthetic peptide corresponding to the C-terminus of human L-plastin protein. This sequence is identical to rat, mouse and human origins
Positive Control
HL60 cells
Cellular Location
Cytoplasmic
Preparation and Storage
The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Other Notes
Small volumes of anti-L-Plastin antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-L-Plastin antibody
L-plastin is a protein normally found in leukocytes (white blood cells) only. In these cells L-plastin regulates cell movement by interacting with actins, a major cellular protein that directly controls cell movement. Normal breast epithelial cells do not have L-plastin. It only presents in breast carcinoma cells. Furthermore, the amount of L-plastin contained in the cells correlates with the degree of invasiveness of these cells. Therefore, it appears that L-plastin may be important for the motility of breast cancer cells.
Applications Tested/Suitable for anti-L-Plastin antibody
ELISA, Western Blot
Application Notes for anti-L-Plastin antibody
Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 0.5-2 ug/ml

Testing Data of anti-L-Plastin antibody
anti-L-Plastin antibody Testing Data image
NCBI/Uniprot data below describe general gene information for L-Plastin. It may not necessarily be applicable to this product.
NCBI GI #
Molecular Weight
~70 kDa
NCBI Official Full Name
L-plastin
UniProt Comments for L-Plastin
L-plastin: Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. Monomer. Interacts with AIF1. Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 13q14.3

Cellular Component: ruffle; extracellular space; focal adhesion; cytoplasm; actin filament bundle; plasma membrane; stress fiber; actin filament; cytosol; actin cytoskeleton; phagocytic cup; filopodium

Molecular Function: actin filament binding; identical protein binding; calcium ion binding; actin binding

Biological Process: actin filament bundle formation; organ regeneration; cell migration; regulation of intracellular protein transport; T cell activation during immune response
Product References and Citations for anti-L-Plastin antibody
Foran,E., et al, The leukocyte protein L-plastin induces proliferation, invasion and loss of E-cadherin expression in colon cancer cells. Int. J. Cancer 118 (8), 2098-2104 (2006)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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