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L1CAM Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2524436

The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
L1CAM, Polyclonal Antibody
Full Product Name
L1CAM Polyclonal Antibody
Product Gene Name
anti-L1CAM antibody
Product Synonym Names
S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purity/Purification
Affinity purification
Preparation and Storage
Store at -20°C. Avoid freeze / thaw cycles.
OMIM
303350
3D Structure
ModBase 3D Structure for P32004
Immunogen
Synthetic peptide of human L1CAM
Note
Centrifuge before opening to ensure complete recovery of vial contents.

Product Categories/Family for anti-L1CAM antibody

Epigenetics
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-L1CAM antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-L1CAM antibody
IHC: 1:25-1:100

Immunohistochemistry (IHC) of anti-L1CAM antibody

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using L1CAM Polyclonal Antibody at dilution 1:40
Rabbit Anti-L1CAM Polyclonal Antibody – Cat# MBS2524436

Immunohistochemistry (IHC) of anti-L1CAM antibody

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using L1CAM Polyclonal Antibody at dilution 1:40
Rabbit Anti-L1CAM Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2524436

Other Notes

Small volumes of anti-L1CAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for L1CAM purchase

MBS2524436 is an antibody targeting L1CAM. Also known as L1CAM Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for L1CAM. It may not necessarily be applicable to this product.

NCBI GI #
19388023
NCBI GeneID
3897
NCBI Accession #
NP_000416
UniProt Primary Accession #
P32004
UniProt Secondary Accession #
Q8TA87; A0AV65; A4ZYW4; B2RMU7; G3XAF4
UniProt Related Accession #
P32004
NCBI Official Full Name
L1CAM protein, partial
NCBI Official Synonym Full Names
L1 cell adhesion molecule
NCBI Official Symbol
L1CAM
NCBI Official Synonym Symbols
S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
UniProt Protein Name
Neural cell adhesion molecule L1
UniProt Synonym Protein Names
CD_antigen: CD171
Protein Family
Neural cell adhesion molecule
UniProt Gene Name
L1CAM
UniProt Synonym Gene Names
CAML1; MIC5; N-CAM-L1; NCAM-L1
UniProt Entry Name
L1CAM_HUMAN
NCBI Protein Information
neural cell adhesion molecule L1; antigen identified by monoclonal antibody R1

UniProt Comments for L1CAM

NCAM-L1: cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons. Two splice-variant isoforms have been described.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: presynaptic membrane; focal adhesion; cell surface; integral to membrane; plasma membrane; terminal button; external side of plasma membrane

Molecular Function: integrin binding; identical protein binding; protein self-association; sialic acid binding

Biological Process: nervous system development; axon guidance; positive regulation of calcium-mediated signaling; chemotaxis; heterophilic cell adhesion; leukocyte adhesion; cell surface receptor linked signal transduction; homotypic cell-cell adhesion; cell-cell adhesion mediated by integrin; positive regulation of cell-cell adhesion; homophilic cell adhesion; blood coagulation; cell adhesion; leukocyte migration

Disease: Hydrocephalus Due To Congenital Stenosis Of Aqueduct Of Sylvius; Corpus Callosum, Partial Agenesis Of, X-linked; Masa Syndrome
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Research Articles on L1CAM

1. Data suggest that miR-34a can regulate L1CAM expression by targeting L1CAM mRNA for degradation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-L1CAM antibody

 Reference Product  PubMed Publications
 NCAM1 antibody  >1490 publications with L1CAM and NCAM1
 CNTN2 antibody  >16 publications with L1CAM and CNTN2
 NCAN antibody  >10 publications with L1CAM and NCAN
 ANK2 antibody  >8 publications with L1CAM and ANK2
 RANBP9 antibody  >1 publications with L1CAM and RANBP9
 CNTN1 antibody  >1 publications with L1CAM and CNTN1
 NUMB antibody  >1 publications with L1CAM and NUMB
 ANK1 antibody  >1 publications with L1CAM and ANK1

Pathways associated with anti-L1CAM antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Interaction Between L1 And Ankyrins Pathway antibodies  Interaction Between L1 And Ankyrins Pathway Diagram

Diseases associated with anti-L1CAM antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >340 publications with L1CAM and Nervous System Diseases
 Brain Diseases Antibodies  >217 publications with L1CAM and Brain Diseases
 Disease Models, Animal Antibodies  >83 publications with L1CAM and Disease Models, Animal
 Adenocarcinoma Antibodies  >52 publications with L1CAM and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >35 publications with L1CAM and Ovarian Neoplasms
 Cardiovascular Diseases Antibodies  >28 publications with L1CAM and Cardiovascular Diseases
 Movement Disorders Antibodies  >25 publications with L1CAM and Movement Disorders
 Aphasia Antibodies  >23 publications with L1CAM and Aphasia
 Neoplasms, Experimental Antibodies  >22 publications with L1CAM and Neoplasms, Experimental
 Learning Disorders Antibodies  >21 publications with L1CAM and Learning Disorders

Organs/Tissues associated with anti-L1CAM antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >836 publications with L1CAM and Brain
 Nerve Antibodies  >457 publications with L1CAM and Nerve
 Embryonic Tissue Antibodies  >108 publications with L1CAM and Embryonic Tissue
 Ganglia Antibodies  >65 publications with L1CAM and Ganglia
 Eye Antibodies  >58 publications with L1CAM and Eye
 Muscle Antibodies  >47 publications with L1CAM and Muscle
 Kidney Antibodies  >39 publications with L1CAM and Kidney
 Skin Antibodies  >31 publications with L1CAM and Skin
 Lung Antibodies  >31 publications with L1CAM and Lung
 Liver Antibodies  >29 publications with L1CAM and Liver
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