Rabbit Anti-LIPE Polyclonal Antibody – Cat# MBS7118411

Western Blot analysis of HuvEc cells using HSL Polyclonal Antibody

LIPE Antibody – Rabbit Polyclonal

Name: LIPE Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS7118411
Price: 185 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7118411

MBS7118411 is an antibody targeting LIPE. Also known as LIPE Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$185 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LIPE, Polyclonal Antibody

Full Product Name

LIPE Antibody

Product Gene Name

anti-LIPE antibody

Product Synonym Names

LIPE; Hormone-sensitive lipase; HSL

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Liquid; In Phosphate Buffered Saline, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.

Purity/Purification

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Preparation and Storage

Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Molecular Weight

116,598 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (42905666..42931578, complement). Location: 19q13.2

OMIM

151750

3D Structure

ModBase 3D Structure for Q05469

Immunogen

Synthesized peptide derived from human HSL around the non-phosphorylation site of S855.

Immunogen Species

Human

Conjugate

Non-conjugated

Product Categories/Family for anti-LIPE antibody

Cardiovascular

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-LIPE antibody

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

Application Notes for anti-LIPE antibody

WB: 1:500-1:2000
IHC: 1:100-1:300
ELISA: 1:5000

Other Notes

Small volumes of anti-LIPE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LIPE. It may not necessarily be applicable to this product.

NCBI GI #

21328446

NCBI GeneID

3991

NCBI Accession #

NP_005348.2

UniProt Primary Accession #

Q05469

UniProt Secondary Accession #

Q3LRT2; Q6NSL7

UniProt Related Accession #

Q05469

GenBank Nucleotide #

NM_005357.2

NCBI Official Full Name

hormone-sensitive lipase

NCBI Official Synonym Full Names

lipase, hormone-sensitive

NCBI Official Symbol

LIPE

NCBI Official Synonym Symbols

HSL; LHS

UniProt Protein Name

Hormone-sensitive lipase

Protein Family

Hormone-sensitive lipase

UniProt Gene Name

LIPE

UniProt Synonym Gene Names

HSL

UniProt Entry Name

LIPS_HUMAN

NCBI Protein Information

hormone-sensitive lipase; hormone-sensitive lipase testicular isoform

NCBI Summary for LIPE

The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]

UniProt Comments for LIPE

HSL: hormone sensitive lipase is a lipolytic enzyme of the 'GDXG' family. Plays a rate limiting step in triglyceride lipolysis. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin.

Protein type: EC 3.1.1.79; Lipase

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: lipid particle; caveola; cytosol

Molecular Function: triacylglycerol lipase activity; hormone-sensitive lipase activity; protein binding; protein kinase binding

Biological Process: cholesterol metabolic process; triacylglycerol catabolic process; diacylglycerol catabolic process; protein amino acid phosphorylation; lipid catabolic process; long-chain fatty acid catabolic process

Disease: Abdominal Obesity-metabolic Syndrome 4

Research Articles on LIPE

1. M. leprae suppresses lipid degradation through inhibition of HSL expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LIPE antibody

Reference Product	PubMed Publications
FABP4 antibody	>2 publications with LIPE and FABP4
PRKACA antibody	>1 publications with LIPE and PRKACA

Pathways associated with anti-LIPE antibody

Products by Pathway	Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Fatty Acid Beta Oxidation Pathway antibodies	Fatty Acid Beta Oxidation Pathway Diagram
Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway antibodies	Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Lipid Digestion, Mobilization, And Transport Pathway antibodies	Lipid Digestion, Mobilization, And Transport Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram

Diseases associated with anti-LIPE antibody

Disease Name	Pubmed Publications
Obesity Antibodies	>19 publications with LIPE and Obesity
Insulin Resistance Antibodies	>11 publications with LIPE and Insulin Resistance
Cardiovascular Diseases Antibodies	>11 publications with LIPE and Cardiovascular Diseases
Drug Toxicity Antibodies	>8 publications with LIPE and Drug Toxicity
Atherosclerosis Antibodies	>6 publications with LIPE and Atherosclerosis
Muscular Diseases Antibodies	>6 publications with LIPE and Muscular Diseases
Hypertension Antibodies	>4 publications with LIPE and Hypertension
Weight Gain Antibodies	>4 publications with LIPE and Weight Gain
Fatty Liver Antibodies	>3 publications with LIPE and Fatty Liver
Diabetes Mellitus Antibodies	>3 publications with LIPE and Diabetes Mellitus

Organs/Tissues associated with anti-LIPE antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>37 publications with LIPE and Blood
Brain Antibodies	>29 publications with LIPE and Brain
Adipose Tissue Antibodies	>19 publications with LIPE and Adipose Tissue
Kidney Antibodies	>6 publications with LIPE and Kidney
Lung Antibodies	>5 publications with LIPE and Lung
Placenta Antibodies	>4 publications with LIPE and Placenta
Embryonic Tissue Antibodies	>4 publications with LIPE and Embryonic Tissue
Eye Antibodies	>3 publications with LIPE and Eye
Adrenal Gland Antibodies	>3 publications with LIPE and Adrenal Gland
Bone Antibodies	>3 publications with LIPE and Bone