MAEA Antibody – Rabbit Polyclonal

This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

MAEA: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Cell development/differentiation; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nucleoplasm; nuclear matrix; cytoskeleton; integral to plasma membrane; cytoplasm; contractile ring; spindle; nucleus

Molecular Function: actin binding

Biological Process: negative regulation of myeloid cell apoptosis; erythrocyte maturation; cell division; regulation of mitotic cell cycle; enucleate erythrocyte development; cytoskeleton organization and biogenesis; cell adhesion; cell cycle