MAP3K11 Antibody – Rabbit Polyclonal

MLK3: a TKL kinase of the MLK family. Has an amino-terminal SH3 domain followed by the kinase domain, two leucine zipper domains, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. Phosphorylates IkappaB and activates SEK1 and MKK7.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; EC 2.7.11.25; Kinase, protein; TKL group; MLK family; MLK subfamily

Chromosomal Location of Human Ortholog: 11q13.1-q13.3

Cellular Component: centrosome; microtubule; membrane; cytoplasm

Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; protein homodimerization activity; JUN kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; protein-tyrosine kinase activity; Rac GTPase binding; mitogen-activated protein kinase kinase kinase binding; ATP binding; protein kinase activity

Biological Process: cell death; cell proliferation; positive regulation of JNK activity; peptidyl-tyrosine phosphorylation; activation of MAPK activity; positive regulation of neuron apoptosis; protein amino acid autophosphorylation; positive regulation of JNK cascade; JNK cascade; protein amino acid phosphorylation; activation of JNK activity; microtubule-based process; activation of JNKK activity