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MBD2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS9131908
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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG… More details

$225 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MBD2, Polyclonal Antibody
Full Product Name
MBD2 Polyclonal Antibody
Product Gene Name
anti-MBD2 antibody
Product Synonym Names
DMTase; NY-CO-41
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
43kDa
OMIM
AF072242 mRNA
3D Structure
ModBase 3D Structure for Q9UBB5
Immunogen
A synthetic peptide of human MBD2
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Product Categories/Family for anti-MBD2 antibody

Primary antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MBD2 antibody
Western Blot (WB)
Application Notes for anti-MBD2 antibody
WB: 1:500 - 1:2000

Western Blot (WB) of anti-MBD2 antibody

Western blot analysis of extracts of various cell lines, using MBD2 antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Rabbit Anti-MBD2 Polyclonal Antibody – Cat# MBS9131908

Other Notes

Small volumes of anti-MBD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MBD2 purchase

MBS9131908 is an antibody targeting MBD2. Also known as MBD2 Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MBD2. It may not necessarily be applicable to this product.

NCBI GI #
50401198
NCBI GeneID
8932
NCBI Accession #
Q9UBB5.1
UniProt Primary Accession #
Q9UBB5
UniProt Secondary Accession #
O95242; Q9UIS8
UniProt Related Accession #
Q9UBB5
NCBI Official Full Name
Methyl-CpG-binding domain protein 2
NCBI Official Synonym Full Names
methyl-CpG binding domain protein 2
NCBI Official Symbol
MBD2
NCBI Official Synonym Symbols
DMTase; NY-CO-41
UniProt Protein Name
Methyl-CpG-binding domain protein 2
UniProt Synonym Protein Names
Demethylase; DMTase; Methyl-CpG-binding protein MBD2
Protein Family
Methyl-CpG-binding domain-containing protein
UniProt Gene Name
MBD2
UniProt Synonym Gene Names
DMTase
NCBI Protein Information
methyl-CpG-binding domain protein 2

UniProt Comments for MBD2

MBD2: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. May enhance the activation of some unmethylated cAMP-responsive promoters. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 18q21.2

Cellular Component: cytosol; nuclear chromatin; nucleoplasm; nucleus; protein complex

Molecular Function: methyl-CpG binding; nucleosomal DNA binding; protein binding; protein domain specific binding; satellite DNA binding

Biological Process: ATP-dependent chromatin remodeling; chromatin silencing at rDNA; methylation-dependent chromatin silencing; negative regulation of transcription from RNA polymerase II promoter
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Research Articles on MBD2

1. MBD2 expression was elevated in HCC tissue, which suggesting MBD2 as a candidate prognostic marker of HCC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MBD2 antibody

 Reference Product  PubMed Publications
 MBD3 antibody  >69 publications with MBD2 and MBD3
 HDAC1 antibody  >26 publications with MBD2 and HDAC1
 HDAC2 antibody  >15 publications with MBD2 and HDAC2
 MTA2 antibody  >5 publications with MBD2 and MTA2
 CHD3 antibody  >3 publications with MBD2 and CHD3
 GATAD2A antibody  >2 publications with MBD2 and GATAD2A
 PRMT5 antibody  >2 publications with MBD2 and PRMT5
 RBBP4 antibody  >2 publications with MBD2 and RBBP4
 GATAD2B antibody  >1 publications with MBD2 and GATAD2B

Pathways associated with anti-MBD2 antibody

 Products by Pathway  Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Negative Epigenetic Regulation Of RRNA Expression Pathway antibodies  Negative Epigenetic Regulation Of RRNA Expression Pathway Diagram
 NoRC Negatively Regulates RRNA Expression Pathway antibodies  NoRC Negatively Regulates RRNA Expression Pathway Diagram
 RNA Polymerase I Promoter Clearance Pathway antibodies  RNA Polymerase I Promoter Clearance Pathway Diagram
 RNA Polymerase I Promoter Opening Pathway antibodies  RNA Polymerase I Promoter Opening Pathway Diagram
 RNA Polymerase I Transcription Pathway antibodies  RNA Polymerase I Transcription Pathway Diagram
 RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies  RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram

Diseases associated with anti-MBD2 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >15 publications with MBD2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >13 publications with MBD2 and Adenocarcinoma
 Disease Models, Animal Antibodies  >12 publications with MBD2 and Disease Models, Animal
 Prostatic Neoplasms Antibodies  >12 publications with MBD2 and Prostatic Neoplasms
 Liver Neoplasms Antibodies  >10 publications with MBD2 and Liver Neoplasms
 Neurobehavioral Manifestations Antibodies  >9 publications with MBD2 and Neurobehavioral Manifestations
 Liver Diseases Antibodies  >8 publications with MBD2 and Liver Diseases
 Neoplasms, Experimental Antibodies  >8 publications with MBD2 and Neoplasms, Experimental
 Brain Diseases Antibodies  >7 publications with MBD2 and Brain Diseases
 Carcinoma, Hepatocellular Antibodies  >6 publications with MBD2 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-MBD2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >48 publications with MBD2 and Blood
 Brain Antibodies  >31 publications with MBD2 and Brain
 Liver Antibodies  >25 publications with MBD2 and Liver
 Lung Antibodies  >20 publications with MBD2 and Lung
 Prostate Antibodies  >17 publications with MBD2 and Prostate
 Nerve Antibodies  >12 publications with MBD2 and Nerve
 Kidney Antibodies  >10 publications with MBD2 and Kidney
 Intestine Antibodies  >9 publications with MBD2 and Intestine
 Embryonic Tissue Antibodies  >8 publications with MBD2 and Embryonic Tissue
 Muscle Antibodies  >7 publications with MBD2 and Muscle
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