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MTMR6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7601646

MBS7601646 is an antibody targeting MTMR6. Also known as MTMR6 Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MTMR6, Polyclonal Antibody
Full Product Name
MTMR6 Rabbit Polyclonal
Product Gene Name
anti-MTMR6 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
63,743 Da
OMIM
603561
Immunogen
Myotubularin related protein 6
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-MTMR6 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-MTMR6 antibody

Immunohistochemistry of paraffin-embedded human liver using MBS7601646 (MTMR6 antibody) at dilution of 1:100
Rabbit Anti-MTMR6 Polyclonal Antibody – Cat# MBS7601646

Western Blot (WB) of anti-MTMR6 antibody

human heart tissue were subjected to SDS PAGE followed by western blot with MBS7601646 (MTMR6 antibody) at dilution of 1:500
Rabbit Anti-MTMR6 Polyclonal Antibody, Western Blot (WB) – Cat# MBS7601646

Other Notes

Small volumes of anti-MTMR6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MTMR6. It may not necessarily be applicable to this product.

NCBI GI #
134142348
NCBI GeneID
9107
NCBI Accession #
NP_004676.3
UniProt Secondary Accession #
Q5JRG6; Q86TB7; Q86YH4; Q96P80; B2RBB5; B3KSB4
UniProt Related Accession #
Q9Y217
GenBank Nucleotide #
NM_004685.3
NCBI Official Full Name
myotubularin-related protein 6
NCBI Official Synonym Full Names
myotubularin related protein 6
NCBI Official Symbol
MTMR6
UniProt Protein Name
Myotubularin-related protein 6
Protein Family
Myotubularin-related protein
UniProt Gene Name
MTMR6
UniProt Entry Name
MTMR6_HUMAN
NCBI Protein Information
myotubularin-related protein 6

UniProt Comments for MTMR6

MTMR6: Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, tyrosine (non-receptor); Phosphatase, lipid; EC 3.1.3.-; Cofactor and Vitamin Metabolism - riboflavin; Carbohydrate Metabolism - fructose and mannose; Cofactor and Vitamin Metabolism - thiamine

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: cytoplasm; cytosol; nuclear envelope

Molecular Function: calcium-activated potassium channel activity; phosphatidylinositol-3-phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; protein amino acid dephosphorylation
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Research Articles on MTMR6

1. MTMR6, which dephosphorylates PI(3)P to PI, and its binding partner MTMR9, are required for macropinocytosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MTMR6 antibody

 Reference Product  PubMed Publications
 MTMR9 antibody  >3 publications with MTMR6 and MTMR9
 INPP4B antibody  >1 publications with MTMR6 and INPP4B
 RAB1B antibody  >1 publications with MTMR6 and RAB1B

Pathways associated with anti-MTMR6 antibody

 Products by Pathway  Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PI Metabolism Pathway antibodies  PI Metabolism Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram
 Phospholipid Metabolism Pathway antibodies  Phospholipid Metabolism Pathway Diagram
 Synthesis Of PIPs At The Plasma Membrane Pathway antibodies  Synthesis Of PIPs At The Plasma Membrane Pathway Diagram

Diseases associated with anti-MTMR6 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >2 publications with MTMR6 and Congenital Abnormalities
 Atherosclerosis Antibodies  >1 publications with MTMR6 and Atherosclerosis
 Kidney Diseases Antibodies  >1 publications with MTMR6 and Kidney Diseases
 Inflammation Antibodies  >1 publications with MTMR6 and Inflammation

Organs/Tissues associated with anti-MTMR6 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with MTMR6 and Blood
 Muscle Antibodies  >2 publications with MTMR6 and Muscle
 Intestine Antibodies  >1 publications with MTMR6 and Intestine
 Kidney Antibodies  >1 publications with MTMR6 and Kidney
 Vascular Antibodies  >1 publications with MTMR6 and Vascular
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