Rabbit Anti-NFIC Polyclonal Antibody – Cat# MBS1753101

NFIC Antibody – Rabbit Polyclonal

Name: NFIC Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1753101
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1753101

Description: Rabbit IgG polyclonal antibody for NFIC/CTF detection. Tested with WB, Direct ELISA in Human; Mouse; Rat.Background: Nuclear factor 1 C-type is a protein that in humans is encoded by the NFIC gene. It is mapped to 19p13.3. The protein encoded by… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NFIC/CTF, Polyclonal Antibody

Full Product Name

Anti-NFIC/CTF Antibody

Product Gene Name

anti-NFIC antibody

Product Synonym Names

Nuclear factor 1 C-type; NF1-C; Nuclear factor 1/C; CCAAT-box-binding transcription factor; CTF; Nuclear factor I/C; NF-I/C; NFI-C; TGGCA-binding protein; NFIC; NFI

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen affinity purified.

Specificity

No cross reactivity with other proteins.

Preparation and Storage

Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.

OMIM

X12492 mRNA

3D Structure

ModBase 3D Structure for P08651

Immunogen

E Coli-derived human NFIC/CTF recombinant protein (Position: D215-G508).

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-NFIC antibody

Western Blot (WB), Direct ELISA (EIA)

Application Notes for anti-NFIC antibody

WB: 0.25-0.5ug/ml (Human, Mouse, Rat)
Direct ELISA: 0.1-0.5ug/ml (Human)
Tested Species: In-house tested species with positive results.

Product References and Citations for anti-NFIC antibody

1. Grunder, A., Qian, F., Ebel, T. T., Mincheva, A., Lichter, P., Kruse, U., Sippel, A. E. Genomic organization, splice products and mouse chromosomal localization of genes for transcription factor nuclear factor one. Gene 304: 171-181, 2003.
2. Qian, F., Kruse, U., Lichter, P., Sippel, A. E. Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. Genomics 28: 66-73, 1995.
3. Steele-Perkins, G., Butz, K. G., Lyons, G. E., Zeichner-David, M., Kim, H.-J., Cho, M.-I., Gronostajski, R. M. Essential role for NFI-C/CTF transcription-replication factor in tooth root development. Molec. Cell. Biol. 23: 1075-1084, 2003.

Other Notes

Small volumes of anti-NFIC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NFIC purchase

MBS1753101 is an antibody targeting NFIC. Also known as Anti-NFIC/CTF Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NFIC. It may not necessarily be applicable to this product.

NCBI GI #

350529396

NCBI GeneID

4782

NCBI Accession #

NP_001231931.1

UniProt Primary Accession #

P08651

UniProt Related Accession #

P08651

GenBank Nucleotide #

NP_001231931.1

NCBI Official Full Name

nuclear factor 1 C-type isoform 1

NCBI Official Synonym Full Names

nuclear factor I C

NCBI Official Symbol

NFIC

NCBI Official Synonym Symbols

CTF; NFI; CTF5; NF-I

UniProt Protein Name

Nuclear factor 1 C-type

UniProt Synonym Protein Names

CCAAT-box-binding transcription factor; CTF; Nuclear factor I/C; NF-I/C; NFI-C; TGGCA-binding protein

Protein Family

Nuclear factor

UniProt Gene Name

NFIC

UniProt Synonym Gene Names

NFI; NF1-C; Nuclear factor 1/C; CTF; NF-I/C; NFI-C

NCBI Protein Information

nuclear factor 1 C-type

NCBI Summary for NFIC

The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

UniProt Comments for NFIC

NFI-C: Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleolus; nucleus

Molecular Function: transcription factor activity

Biological Process: negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

Research Articles on NFIC

1. Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 x 10(-8)) were identified for the interaction of the (apolipoprotein E) APOE epsilon4 allele with NFIC SNP.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NFIC antibody

Products by Pathway	Pathway Diagram
FOXA1 Transcription Factor Network Pathway antibodies	FOXA1 Transcription Factor Network Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies	RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
RNA Polymerase III Abortive And Retractive Initiation Pathway antibodies	RNA Polymerase III Abortive And Retractive Initiation Pathway Diagram
RNA Polymerase III Transcription Pathway antibodies	RNA Polymerase III Transcription Pathway Diagram
RNA Polymerase III Transcription Termination Pathway antibodies	RNA Polymerase III Transcription Termination Pathway Diagram

Diseases associated with anti-NFIC antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>3 publications with NFIC and Nervous System Diseases
Inflammation Antibodies	>3 publications with NFIC and Inflammation
Carcinoma Antibodies	>3 publications with NFIC and Carcinoma
Brain Diseases Antibodies	>2 publications with NFIC and Brain Diseases
Cell Transformation, Neoplastic Antibodies	>2 publications with NFIC and Cell Transformation, Neoplastic
Breast Neoplasms Antibodies	>2 publications with NFIC and Breast Neoplasms
Acute Kidney Injury Antibodies	>1 publications with NFIC and Acute Kidney Injury
Adenocarcinoma Antibodies	>1 publications with NFIC and Adenocarcinoma
Heart Diseases Antibodies	>1 publications with NFIC and Heart Diseases
Weight Loss Antibodies	>1 publications with NFIC and Weight Loss

Organs/Tissues associated with anti-NFIC antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>16 publications with NFIC and Brain
Mouth Antibodies	>14 publications with NFIC and Mouth
Liver Antibodies	>14 publications with NFIC and Liver
Bone Antibodies	>12 publications with NFIC and Bone
Lung Antibodies	>7 publications with NFIC and Lung
Embryonic Tissue Antibodies	>6 publications with NFIC and Embryonic Tissue
Kidney Antibodies	>4 publications with NFIC and Kidney
Mammary Gland Antibodies	>3 publications with NFIC and Mammary Gland
Spleen Antibodies	>3 publications with NFIC and Spleen
Blood Antibodies	>3 publications with NFIC and Blood